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    Examining Persistence for Ibrance (palbociclib) for FDA Approved indication and dosing through a retrospective analysis

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    Group 3 Ibrance Poster.pdf
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    Poster
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    Author
    Alanis, Elizabeth
    Leon, Terra
    Ochoa, Nicole
    Tschida, Melanie
    Affiliation
    College of Pharmacy, The University of Arizona
    Issue Date
    2019
    Keywords
    Ibrance
    Palbociclib
    FDA Approved
    Retrospective Analysis
    Metastatic Breast Cancer
    Letrozole
    Fulvestrant
    Medication Adherence
    Therapy
    MeSH Subjects
    Breast Neoplasms
    United States Food and Drug Administration
    Letrozole
    Fulvestrant
    Medication Adherence
    Advisor
    Mathews, Kelly
    Gianninoto, Jenna
    Slack, Marion
    
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    Rights
    Copyright © is held by the author.
    Collection Information
    This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
    Publisher
    The University of Arizona.
    Abstract
    Specific Aims: To determine whether receiving all medication therapy from a single pharmacy positively impacts medication adherence and lengthens duration of therapy in patients who are taking palbociclib for the treatment of HR+, HER2- metastatic breast cancer. Methods: In a retrospective cohort study, we analyzed 347 patients concurrently taking palbociclib and letrozole or fulvestrant. Patients with HR+, HER2- metastatic breast cancer currently on combination therapy of palbociclib and letrozole or fulvestrant filling at Avella Specialty Pharmacy between March 2016 to December 2017. Patients were divided into two groups characterized by those that filled both agents at Avella Specialty Pharmacy and those that only filled palbociclib at Avella and the other agent at a retail pharmacy. We compared the mean length of therapy, the PDC mean, and payor type between both patient groups. Primary outcome was the Proportion of Days Covered (PDC). Secondary outcomes included days on therapy and payor type. Main Results: Data analysis was conducted among the 347 patients (mean age = 69.37; SD = 11.40). Comparison of PDC mean resulted in no significant difference (SPP mean = 94.5%, SD = 0.11; Non-SPP mean = 95.06%, SD = 0.09; t-test p-value = 0.82/Mann-Whitney U test p-value = 0.76). Days on therapy presented no significant difference (SPP mean = 177.81, SD = 136.95; Non-SPP mean = 173.09, SD 157.69; t-test p-value= 0.83/Mann-Whitney U test p-value: 0.07). Comparison of payor type between patient groups had no significant difference (p-value = 0.13). Conclusions: Adherence and length of therapy for patients filling both agents at Avella were similar to those filling the second agent at an alternative retail pharmacy.
    Description
    Class of 2019 Abstract, Poster, and Paper
    Collections
    Pharmacy Student Research Projects

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