Prescribing Habits of Citalopram at El Rio Health Center for Patients Older than 60 Years of Age

Abstract

Specific Aims: To analyze current prescribing habits of citalopram in patients over 60 years of age and to identify concomitant use of cytochrome P450 2C19 (CYP2C19) inhibitors with citalopram at any dose. Subjects: El Rio Health patients that are greater than 60 years of age and are receiving citalopram

Methods: A retrospective chart review was conducted to collect data on El Rio patients over 60 years of age that were prescribed citalopram. The citalopram dose and use of concomitant CYP2C19 inhibitors were recorded for these patients. Demographic data including age, gender, and race along with various labs such as EKG, QTC, liver function, kidney function, and PHQ-9 were also collected if available.

Main Results: 45.1% vs. 23.5% were on concomitant CYP2C19 inhibitors with citalopram at doses less than 40 mg group versus with citalopram at doses greater than 40 mg respectively (p<0.001).

Conclusions: In patients over 60 years old, there were a greater number prescribed citalopram at dose less than 40 mg than at doses greater than 40 mg, and there were also fewer patients concomitantly taking CYP2C19 inhibitors with citalopram at doses greater than 40 mg than those concomitantly taking CYP2C19 inhibitors with citalopram at doses less than 40 mg.