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dc.contributor.authorTorre, Yanira Sanchez-De la
dc.contributor.authorWadeea, Rita
dc.contributor.authorRosas, Victoria
dc.contributor.authorHerbst, Karen L
dc.date.accessioned2019-11-21T00:18:52Z
dc.date.available2019-11-21T00:18:52Z
dc.date.issued2018-03-09
dc.identifier.citationHormone Molecular Biology and Clinical Investigation, Volume 33, Issue 1, 20170076, ISSN (Online) 1868-1891, DOI: https://doi.org/10.1515/hmbci-2017-0076.en_US
dc.identifier.issn1868-1883
dc.identifier.pmid29522416
dc.identifier.doi10.1515/hmbci-2017-0076
dc.identifier.urihttp://hdl.handle.net/10150/636233
dc.description.abstractBackground: Lipedema is a chronic disorder presenting in women during puberty or other times of hormonal change such as childbirth or menopause, characterized by symmetric enlargement of nodular, painful subcutaneous adipose tissue (fat) in the limbs, sparing the hands, feet and trunk. Healthcare providers underdiagnose or misdiagnose lipedema as obesity or lymphedema. Materials and methods: The benefits (friend) and negative aspects (foe) of lipedema were collected from published literature, discussions with women with lipedema, and institutional review board approved evaluation of medical charts of 46 women with lipedema. Results: Lipedema is a foe because lifestyle change does not reduce lipedema fat, the fat is painful, can become obese, causes gait and joint abnormalities, fatigue, lymphedema and psychosocial distress. Hypermobility associated with lipedema can exacerbate joint disease and aortic disease. In contrast, lipedema fat can be a friend as it is associated with relative reductions in obesity-related metabolic dysfunction. In new data collected, lipedema was associated with a low risk of diabetes (2%), dyslipidemia (11.7%) and hypertension (13%) despite an obese average body mass index (BMI) of 35.3 +/- 1.7 kg/m(2). Conclusion: Lipedema is a painful psychologically distressing fat disorder, more foe than friend especially due to associated obesity and lymphedema. More controlled studies are needed to study the mechanisms and treatments for lipedema.en_US
dc.description.sponsorshipLipedema Foundation; National Institute of General Medical Sciences of the National Institutes of Health [RL5GM118969, TL4GM 118971, UL1GM118970, 10.13039/100000002]en_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.rightsCopyright © 2018 Walter de Gruyter GmbH, Berlin/Boston.en_US
dc.subjectgynoid faten_US
dc.subjecthypermobilityen_US
dc.subjectlipedemaen_US
dc.subjectlymphedemaen_US
dc.subjectwomenen_US
dc.titleLipedema: friend and foeen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Med, TREAT Programen_US
dc.identifier.journalHORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATIONen_US
dc.description.note12 month embargo; published online: 9 March 2018en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleHormone molecular biology and clinical investigation
refterms.dateFOA2019-03-09T00:00:00Z


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