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dc.contributor.authorGoldbaum, Daniel S
dc.contributor.authorHurley, Justin D
dc.contributor.authorHamilton, Russell J
dc.date.accessioned2019-12-13T00:35:05Z
dc.date.available2019-12-13T00:35:05Z
dc.date.issued2019-11-19
dc.identifier.citationGoldbaum, D. S., Hurley, J. D., & Hamilton, R. J. (2019). A simple knowledge‐based tool for stereotactic radiosurgery pre‐planning. Journal of applied clinical medical physics.en_US
dc.identifier.issn1526-9914
dc.identifier.pmid31743563
dc.identifier.doi10.1002/acm2.12770
dc.identifier.urihttp://hdl.handle.net/10150/636361
dc.description.abstractWe studied the dosimetry of single-isocenter treatment plans generated to treat a solitary intracranial lesion using linac-based stereotactic radiosurgery (SRS). A common metric for evaluating SRS plan quality is the volume of normal brain tissue irradiated by a dose of at least 12 Gy (V12), which is important because multiple studies have shown a strong correlation between V12 and incidence of radiation necrosis. Unrealistic expectations for values of V12 can lead to wasted planning time. We present a model that estimates V12 without having to construct a full treatment plan. This model was derived by retrospectively analyzing 50 SRS treatment plans, each clinically approved for delivery using circular collimator cone arc therapy (CAT). Each case was re-planned for delivery via dynamic conformal arc therapy (DCAT), and then scaling arguments were used to extend dosimetric data to account for different prescription dose (PD) values (15, 18, 21, or 24 Gy). We determined a phenomenological expression for the total volume receiving at least 12 Gy (TV12) as a function of both planning target volume (PTV) and PD: T V 12 / 1 c c = n ∗ P D / 1 G y + d ∗ P T V / 1 c c a ∗ P D / 1 G y c , where a , c , n , d are fit parameters, and a separate set of values is determined for each plan type. In addition, we generated a sequence of plots to clarify how the relationship between conformity index (CI) and TV12 depends on plan type (CAT vs DCAT), PTV, and PD. These results can be used to suggest realistic plan parameters and planning goals before the start of treatment planning. In the absence of access to more sophisticated pre-planning tools, this model can be locally generated and implemented at relatively low cost with respect to time, money, and expertise.en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.rightsCopyright © 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectV12en_US
dc.subjectcircular arc therapy (CAT)en_US
dc.subjectconformity index (CI)en_US
dc.subjectdynamic conformal arc therapy (DCAT)en_US
dc.subjectmodelingen_US
dc.subjectstereotactic radiosurgery (SRS)en_US
dc.titleA simple knowledge-based tool for stereotactic radiosurgery pre-planningen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Radiat Oncolen_US
dc.identifier.journalJOURNAL OF APPLIED CLINICAL MEDICAL PHYSICSen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleJournal of applied clinical medical physics
refterms.dateFOA2019-12-13T00:35:05Z


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