Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions
Simpson, Richard J
Orange, Jordan S
Smith, Scott M
Zwart, Sara R
Stowe, Raymond P
Frippiat, Jean P
Douglas, Grace L
Krieger, Stephanie S
Ginsburg, Geoffrey S
Ott, C Mark
AffiliationUniv Arizona, Dept Nutr Sci
Univ Arizona, Dept Pediat
Univ Arizona, Dept Immunobiol
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationMakedonas G, Mehta S, Choukèr A, Simpson RJ, Marshall G, Orange JS, Aunon-Chancellor S, Smith SM, Zwart SR, Stowe RP, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Krieger SS, Lorenzi H, Buchheim J-I, Ginsburg GS, Ott CM, Downs M, Pierson D, Baecker N, Sams C and Crucian B (2019) Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions. Front. Immunol. 10:2407. doi: 10.3389/fimmu.2019.02407
JournalFRONTIERS IN IMMUNOLOGY
RightsCopyright © 2019 Makedonas, Mehta, Choukèr, Simpson, Marshall, Orange, Aunon-Chancellor, Smith, Zwart, Stowe, Heer, Ponomarev, Whitmire, Frippiat, Douglas, Krieger, Lorenzi, Buchheim, Ginsburg, Ott, Downs, Pierson, Baecker, Sams and Crucian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractHistorically, serious illness of astronauts on orbit is rare, however clinical episodes requiring therapeutic intervention have occurred during International Space Station (ISS) missions at a noteworthy rate (1, 2). Persistent exposure to the space environment exacerbates perturbations to the immune system (3). In support, the NASA “twins” study—an evaluation of a crewmember during a 1-year ISS mission—revealed significant changes between in-flight and non-flight time points in the gene expression patterns of several immune response pathways, DNA methylation patterns of genes that regulate T cell responses, and the signatures of plasma cytokines, to promote during spaceflight decreased cellular responsiveness and increased inflammation (4). Because future deep-space exploration missions will endure for an unprecedented amount of time, with increased magnitude of mission-associated stressors, it is reasonable to expect a higher incidence of morbidities. Previously, we published a comprehensive review of potential countermeasures to obviate the immune “problem” associated with spaceflight. Now, we present a specific and personalized immune countermeasure prescription for prospective astronauts embarking on deep-space voyage
NoteOpen access journal
VersionFinal published version
SponsorsGerman National Space Program [50WB1622]; European Space Agency (ESA)'s Topical Team Stress and Immunity - ESA ELIPS 4 program; European Space Agency (ESA)'s Topical Team Stress and Immunity - ESA SciSpacE program
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