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dc.contributor.authorMakedonas, George
dc.contributor.authorMehta, Satish
dc.contributor.authorChoukèr, Alexander
dc.contributor.authorSimpson, Richard J
dc.contributor.authorMarshall, Gailen
dc.contributor.authorOrange, Jordan S
dc.contributor.authorAunon-Chancellor, Serena
dc.contributor.authorSmith, Scott M
dc.contributor.authorZwart, Sara R
dc.contributor.authorStowe, Raymond P
dc.contributor.authorHeer, Martina
dc.contributor.authorPonomarev, Sergey
dc.contributor.authorWhitmire, Alexandra
dc.contributor.authorFrippiat, Jean P
dc.contributor.authorDouglas, Grace L
dc.contributor.authorKrieger, Stephanie S
dc.contributor.authorLorenzi, Hernan
dc.contributor.authorBuchheim, Judith-Irina
dc.contributor.authorGinsburg, Geoffrey S
dc.contributor.authorOtt, C Mark
dc.contributor.authorDowns, Meghan
dc.contributor.authorPierson, Duane
dc.contributor.authorBaecker, Natalie
dc.contributor.authorSams, Clarence
dc.contributor.authorCrucian, Brian
dc.date.accessioned2019-12-18T17:12:48Z
dc.date.available2019-12-18T17:12:48Z
dc.date.issued2019-10-11
dc.identifier.citationMakedonas G, Mehta S, Choukèr A, Simpson RJ, Marshall G, Orange JS, Aunon-Chancellor S, Smith SM, Zwart SR, Stowe RP, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Krieger SS, Lorenzi H, Buchheim J-I, Ginsburg GS, Ott CM, Downs M, Pierson D, Baecker N, Sams C and Crucian B (2019) Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions. Front. Immunol. 10:2407. doi: 10.3389/fimmu.2019.02407en_US
dc.identifier.issn1664-3224
dc.identifier.pmid31681296
dc.identifier.doi10.3389/fimmu.2019.02407
dc.identifier.urihttp://hdl.handle.net/10150/636434
dc.description.abstractHistorically, serious illness of astronauts on orbit is rare, however clinical episodes requiring therapeutic intervention have occurred during International Space Station (ISS) missions at a noteworthy rate (1, 2). Persistent exposure to the space environment exacerbates perturbations to the immune system (3). In support, the NASA “twins” study—an evaluation of a crewmember during a 1-year ISS mission—revealed significant changes between in-flight and non-flight time points in the gene expression patterns of several immune response pathways, DNA methylation patterns of genes that regulate T cell responses, and the signatures of plasma cytokines, to promote during spaceflight decreased cellular responsiveness and increased inflammation (4). Because future deep-space exploration missions will endure for an unprecedented amount of time, with increased magnitude of mission-associated stressors, it is reasonable to expect a higher incidence of morbidities. Previously, we published a comprehensive review of potential countermeasures to obviate the immune “problem” associated with spaceflight. Now, we present a specific and personalized immune countermeasure prescription for prospective astronauts embarking on deep-space voyageen_US
dc.description.sponsorshipGerman National Space Program [50WB1622]; European Space Agency (ESA)'s Topical Team Stress and Immunity - ESA ELIPS 4 program; European Space Agency (ESA)'s Topical Team Stress and Immunity - ESA SciSpacE programen_US
dc.language.isoenen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.rightsCopyright © 2019 Makedonas, Mehta, Choukèr, Simpson, Marshall, Orange, Aunon-Chancellor, Smith, Zwart, Stowe, Heer, Ponomarev, Whitmire, Frippiat, Douglas, Krieger, Lorenzi, Buchheim, Ginsburg, Ott, Downs, Pierson, Baecker, Sams and Crucian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHerpesvirus reactivationen_US
dc.subjectimmune countermeasuresen_US
dc.subjectimmune surveillanceen_US
dc.subjectspace immunologyen_US
dc.subjectstress managementen_US
dc.titleSpecific Immunologic Countermeasure Protocol for Deep-Space Exploration Missionsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Nutr Scien_US
dc.contributor.departmentUniv Arizona, Dept Pediaten_US
dc.contributor.departmentUniv Arizona, Dept Immunobiolen_US
dc.identifier.journalFRONTIERS IN IMMUNOLOGYen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleFrontiers in immunology
refterms.dateFOA2019-12-18T17:12:49Z


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Copyright © 2019 Makedonas, Mehta, Choukèr, Simpson, Marshall, Orange, Aunon-Chancellor, Smith, Zwart, Stowe, Heer, Ponomarev, Whitmire, Frippiat, Douglas, Krieger, Lorenzi, Buchheim, Ginsburg, Ott, Downs, Pierson, Baecker, Sams and Crucian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as Copyright © 2019 Makedonas, Mehta, Choukèr, Simpson, Marshall, Orange, Aunon-Chancellor, Smith, Zwart, Stowe, Heer, Ponomarev, Whitmire, Frippiat, Douglas, Krieger, Lorenzi, Buchheim, Ginsburg, Ott, Downs, Pierson, Baecker, Sams and Crucian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).