Show simple item record

dc.contributor.authorZhou, Yang
dc.contributor.authorBanday, Abid H
dc.contributor.authorHruby, Victor J
dc.contributor.authorCai, Minying
dc.date.accessioned2019-12-18T17:50:20Z
dc.date.available2019-12-18T17:50:20Z
dc.date.issued2019-09-27
dc.identifier.citationZhou, Y., Banday, A. H., Hruby, V. J., & Cai, M. (2019). Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists. Molecules, 24(19), 3512.en_US
dc.identifier.issn1420-3049
dc.identifier.pmid31569697
dc.identifier.doi10.3390/molecules24193512
dc.identifier.urihttp://hdl.handle.net/10150/636442
dc.description.abstractCancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses. The Toll-like receptor 2 and 6 (TLR2/TLR6) agonist dipalmitoyl-S-glyceryl cysteine (Pam2Cys) was demonstrated as an ideal candidate for synthetic vaccine adjuvants. However, the synthesis of Pam2Cys requires expensive N-protected cysteine as a key reactant, which greatly limits its application as a synthetic vaccine adjuvant in large-scaled studies. Here, we report the development of N-acetylated Pam2Cys analogs as TLR2/TLR6 agonists. Instead of N-protected cysteine, the synthesis utilizes N-acetylcysteine to bring down the synthetic costs. The N-acetylated Pam2Cys analogs were demonstrated to activate TLR2/TLR6 in vitro. Moreover, molecular docking studies were performed to provide insights into the molecular mechanism of how N-acetylated Pam2Cys analogs bind to TLR2/TLR6. Together, these results suggest N-acetylated Pam2Cys analogs as inexpensive and promising synthetic vaccine adjuvants to accelerate the development of cancer vaccines in the future.en_US
dc.description.sponsorshipUS Public Health Service, NIH NIDA [RO1 DA 13449]en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsCopyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectN-acetylated Pam2Cysen_US
dc.subjectPam2Cysen_US
dc.subjectToll-like receptoren_US
dc.subjectadjuvanten_US
dc.subjectcancer vaccineen_US
dc.subjectsynthetic vaccineen_US
dc.titleDevelopment of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonistsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Chem & Biochemen_US
dc.identifier.journalMOLECULESen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleMolecules (Basel, Switzerland)
refterms.dateFOA2019-12-18T17:50:20Z


Files in this item

Thumbnail
Name:
molecules-24-03512.pdf
Size:
2.842Mb
Format:
PDF
Description:
Final Published Version

This item appears in the following Collection(s)

Show simple item record