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dc.contributor.authorMorera, Andrés A
dc.contributor.authorAhmed, Nasiha S
dc.contributor.authorSchwartz, Jacob C
dc.date.accessioned2020-01-17T20:27:09Z
dc.date.available2020-01-17T20:27:09Z
dc.date.issued2019-10
dc.identifier.citationMorera, A. A., Ahmed, N. S., & Schwartz, J. C. (2019). TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1862(10), 194434.en_US
dc.identifier.issn1874-9399
dc.identifier.pmid31655156
dc.identifier.doi10.1016/j.bbagrm.2019.194434
dc.identifier.urihttp://hdl.handle.net/10150/636496
dc.description.abstractThe 43-kDa transactive response DNA-binding protein (TDP-43) is an example of an RNA-binding protein that regulates RNA metabolism at multiple levels from transcription and splicing to translation. Its role in post-transcriptional RNA processing has been a primary focus of recent research, but its role in regulating transcription has been studied for only a few human genes. We characterized the effects of TDP-43 on transcription genome-wide and found that TDP-43 broadly affects transcription of protein-coding and noncoding RNA genes. Among protein-coding genes, the effects of TDP-43 were greatest for genes < 30 thousand base pairs in length. Surprisingly, we found that the loss of TDP-43 resulted in increased evidence for transcription activity near repetitive Alu elements found within expressed genes. The highest densities of affected Alu elements were found in the shorter genes, whose transcription was most affected by TDP-43. Thus, in addition to its role in post-transcriptional RNA processing, TDP-43 plays a critical role in maintaining the transcriptional stability of protein-coding genes and transposable DNA elements.en_US
dc.description.sponsorshipNational Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [NS082376]; Office of the Director, National Institutes of Health of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [S10OD013237]en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.rights© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAlu SINEen_US
dc.subjectGRO-seqen_US
dc.subjectRetrotransposonen_US
dc.subjectTARDBPen_US
dc.subjectTDP-43en_US
dc.subjectTranscriptionen_US
dc.titleTDP-43 regulates transcription at protein-coding genes and Alu retrotransposonsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Mol & Cellular Biolen_US
dc.contributor.departmentUniv Arizona, Dept Chem & Biochemen_US
dc.identifier.journalBIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMSen_US
dc.description.noteOpen access articleen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleBiochimica et biophysica acta. Gene regulatory mechanisms
refterms.dateFOA2020-01-17T20:27:10Z


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© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).