Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis
AffiliationUniv Arizona, Dept Obstet & Gynecol, Coll Med Phoenix
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CitationMaarsingh, J.D., Yang, S., Park, J.G. et al. Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis. BMC Genomics 20, 942 (2019) doi:10.1186/s12864-019-6105-3
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AbstractThe M. smegmatis PrrAB two-component system regulates respiratory and oxidative phosphorylation pathways, potentially to provide tolerance against the dynamic environmental conditions experienced in its natural ecological niche. PrrAB positively regulates ATP levels during exponential growth, presumably through transcriptional activation of both terminal respiratory branches (cytochrome c bc1-aa3 and cytochrome bd oxidases), despite transcriptional repression of ATP synthase genes. Additionally, PrrAB positively regulates expression of the dormancy-associated dosR response regulator genes in an oxygen-independent manner, which may serve to fine-tune sensory perception of environmental stimuli associated with metabolic repression.
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- Authors: Mayuri, Bagchi G, Das TK, Tyagi JS
- Issue date: 2002 Jun 4
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- Authors: Haydel SE, Malhotra V, Cornelison GL, Clark-Curtiss JE
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- The dormancy regulator DosR controls ribosome stability in hypoxic mycobacteria.
- Authors: Trauner A, Lougheed KE, Bennett MH, Hingley-Wilson SM, Williams HD
- Issue date: 2012 Jul 6