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    Intentional Weight Loss and Obesity-Related Cancer Risk

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    Author
    Luo, Juhua
    Hendryx, Michael
    Manson, JoAnn E
    Figueiredo, Jane C
    LeBlanc, Erin S
    Barrington, Wendy
    Rohan, Thomas E
    Howard, Barbara V
    Reding, Kerryn
    Ho, Gloria Yf
    Garcia, David O
    Chlebowski, Rowan T
    Show allShow less
    Affiliation
    Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth
    Issue Date
    2019-08-09
    
    Metadata
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    Publisher
    OXFORD UNIV PRESS
    Citation
    Juhua Luo, Michael Hendryx, JoAnn E Manson, Jane C Figueiredo, Erin S LeBlanc, Wendy Barrington, Thomas E Rohan, Barbara V Howard, Kerryn Reding, Gloria Yf Ho, David O Garcia, Rowan T Chlebowski, Intentional Weight Loss and Obesity-Related Cancer Risk, JNCI Cancer Spectrum, Volume 3, Issue 4, December 2019, pkz054, https://doi.org/10.1093/jncics/pkz054
    Journal
    JNCI CANCER SPECTRUM
    Rights
    Copyright © The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background: Epidemiologic studies regarding weight loss and subsequent cancer risk are sparse. The study aim was to evaluate the association between weight change by intentionality and obesity-related cancer incidence in the Women's Health Initiative Observational Study. Eleven cancers were considered obesity related: breast, ovary, endometrium, colon and rectum, esophagus, kidney, liver, multiple myeloma, pancreas, stomach, and thyroid. Methods: Postmenopausal women (n = 58 667) aged 50-79 years had body weight and waist circumference (WC) measured at baseline and year 3. Weight or WC change was categorized as stable (change < +/- 5%), loss (>= 5%), and gain (>= 5%). Self-report at year 3 characterized weight loss as intentional or unintentional. During the subsequent 12 years (mean) of follow-up, 6033 incident obesity-related cancers were identified. Relationships were evaluated using multivariable Cox proportional hazards regression models. Results: Compared to women with stable weight, women with intentional weight loss had lower obesity-related cancer risk (hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.80 to 0.98). A similar result was observed for intentional WC reduction (HR = 0.88, 95% CI = 0.80 to 0.96). Among all cancers, intentional weight loss was most strongly associated with endometrial cancer (HR = 0.61, 95% CI = 0.42 to 0.88). Intentional WC loss was also associated with lower colorectal cancer risk (HR = 0.79, 95% CI = 0.63 to 0.99). Unintentional weight loss or weight gain was not associated with overall obesity-related cancer risk. Conclusion: Intentional weight or WC loss in postmenopausal women was associated with lower risk of obesity-related cancer. These findings suggest that postmenopausal women who intentionally lose weight can reduce their obesity-related cancer risk.
    Note
    Open access journal
    ISSN
    2515-5091
    PubMed ID
    31737862
    DOI
    10.1093/jncics/pkz054
    Version
    Final published version
    Sponsors
    U.S. Department of Health and Human Services, National Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C]
    ae974a485f413a2113503eed53cd6c53
    10.1093/jncics/pkz054
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