Manson, JoAnn E
Figueiredo, Jane C
LeBlanc, Erin S
Rohan, Thomas E
Howard, Barbara V
Ho, Gloria Yf
Garcia, David O
Chlebowski, Rowan T
AffiliationUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth
MetadataShow full item record
PublisherOXFORD UNIV PRESS
CitationJuhua Luo, Michael Hendryx, JoAnn E Manson, Jane C Figueiredo, Erin S LeBlanc, Wendy Barrington, Thomas E Rohan, Barbara V Howard, Kerryn Reding, Gloria Yf Ho, David O Garcia, Rowan T Chlebowski, Intentional Weight Loss and Obesity-Related Cancer Risk, JNCI Cancer Spectrum, Volume 3, Issue 4, December 2019, pkz054, https://doi.org/10.1093/jncics/pkz054
JournalJNCI CANCER SPECTRUM
RightsCopyright © The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact email@example.com.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground: Epidemiologic studies regarding weight loss and subsequent cancer risk are sparse. The study aim was to evaluate the association between weight change by intentionality and obesity-related cancer incidence in the Women's Health Initiative Observational Study. Eleven cancers were considered obesity related: breast, ovary, endometrium, colon and rectum, esophagus, kidney, liver, multiple myeloma, pancreas, stomach, and thyroid. Methods: Postmenopausal women (n = 58 667) aged 50-79 years had body weight and waist circumference (WC) measured at baseline and year 3. Weight or WC change was categorized as stable (change < +/- 5%), loss (>= 5%), and gain (>= 5%). Self-report at year 3 characterized weight loss as intentional or unintentional. During the subsequent 12 years (mean) of follow-up, 6033 incident obesity-related cancers were identified. Relationships were evaluated using multivariable Cox proportional hazards regression models. Results: Compared to women with stable weight, women with intentional weight loss had lower obesity-related cancer risk (hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.80 to 0.98). A similar result was observed for intentional WC reduction (HR = 0.88, 95% CI = 0.80 to 0.96). Among all cancers, intentional weight loss was most strongly associated with endometrial cancer (HR = 0.61, 95% CI = 0.42 to 0.88). Intentional WC loss was also associated with lower colorectal cancer risk (HR = 0.79, 95% CI = 0.63 to 0.99). Unintentional weight loss or weight gain was not associated with overall obesity-related cancer risk. Conclusion: Intentional weight or WC loss in postmenopausal women was associated with lower risk of obesity-related cancer. These findings suggest that postmenopausal women who intentionally lose weight can reduce their obesity-related cancer risk.
NoteOpen access journal
VersionFinal published version
SponsorsU.S. Department of Health and Human Services, National Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C]
- Intentional Weight Loss and Endometrial Cancer Risk.
- Authors: Luo J, Chlebowski RT, Hendryx M, Rohan T, Wactawski-Wende J, Thomson CA, Felix AS, Chen C, Barrington W, Coday M, Stefanick M, LeBlanc E, Margolis KL
- Issue date: 2017 Apr 10
- Weight loss and breast cancer incidence in postmenopausal women.
- Authors: Chlebowski RT, Luo J, Anderson GL, Barrington W, Reding K, Simon MS, Manson JE, Rohan TE, Wactawski-Wende J, Lane D, Strickler H, Mosaver-Rahmani Y, Freudenheim JL, Saquib N, Stefanick ML
- Issue date: 2019 Jan 15
- Weight Fluctuation and Cancer Risk in Postmenopausal Women: The Women's Health Initiative.
- Authors: Welti LM, Beavers DP, Caan BJ, Sangi-Haghpeykar H, Vitolins MZ, Beavers KM
- Issue date: 2017 May
- Intentional weight loss and incidence of obesity-related cancers: the Iowa Women's Health Study.
- Authors: Parker ED, Folsom AR
- Issue date: 2003 Dec
- Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials.
- Authors: Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM, Thomson CA, Caan BJ, Tinker LF, Urrutia RP, Knudtson J, Anderson GL
- Issue date: 2015 Aug