Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts
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Univ Arizona, Sch Anim & Comparat Biomed SciIssue Date
2019-11-04Keywords
Agaricus blazei Murillantidiabetic activity
antioxidant activity
HepG2 cells
alpha-glucosidase
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WILEYCitation
Wei Q, Zhan Y, Chen B, et al. Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts. Food Sci Nutr. 2019;00:1–8. https ://doi.org/10.1002/fsn3.1310Journal
FOOD SCIENCE & NUTRITIONRights
Copyright © 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 '-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3Fe(CN)(6) in vitro. Moreover, the effects of EE and EA on alpha-glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of alpha-glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose-lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.Note
Open access journalISSN
2048-7177Version
Final published versionSponsors
Modern Agricultural Technology System of Edible Fungi Industry in Fujian Province [K83139295]; National Natural Science Foundation of China [31401597]ae974a485f413a2113503eed53cd6c53
10.1002/fsn3.1310