Tribal warfare: Commensal Neisseria kill pathogen Neisseria gonorrhoeae using its DNA
AffiliationUniv Arizona, BIO5 Inst
Univ Arizona, Dept Immunobiol
MetadataShow full item record
PublisherSHARED SCIENCE PUBLISHERS OG
CitationMagdalene So and Maria A. Rendón (2019). Tribal warfare: Commensal Neisseria kill pathogen Neisseria gonorrhoeae using its DNA. Microbial Cell 6(12): 544- 546. doi: 10.15698/mic2019.12.701
RightsCopyright © 2019 So and Rendón. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractIt is now abundantly clear that our microbiota (commensals) are critical for many physiological and developmental processes. They have also been shown to inhibit pathogen colonization, through a variety of means including nutrient competition and secretion of microbicidal or biofilm-inhibiting proteins/peptides. Our recent study, Kim et al., (2019), adds a new dimension to the concept of commensal protection. It shows that commensal Neisseria kill the closely related pathogen N. gonorrhoeae through an unexpected mechanism, one that involves genetic competence, DNA methylation state and recombination. This microreview summarizes the report and discusses questions and lines of research arising from the study. Further investigation into this DNA-based killing mechanism will provide a better understanding of Neisseria biology and commensal-pathogen interactions on the mucosa, and identify strategies for preventing pathogenic Neisseria transmission.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AI111944]; BIO5 Institute of the University of Arizona; College of Medicine of the University of Arizona
Except where otherwise noted, this item's license is described as Copyright © 2019 So and Rendón. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license.
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