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dc.contributor.authorMontoya, Justin J
dc.contributor.authorTurnidge, Megan A
dc.contributor.authorWai, Daniel H
dc.contributor.authorPatel, Apurvi R
dc.contributor.authorLee, David W
dc.contributor.authorGokhale, Vijay
dc.contributor.authorHurley, Laurence H
dc.contributor.authorArceci, Robert J
dc.contributor.authorWetmore, Cynthia
dc.contributor.authorAzorsa, David O
dc.date.accessioned2020-01-29T22:54:15Z
dc.date.available2020-01-29T22:54:15Z
dc.date.issued2019-12-27
dc.identifier.citationMontoya, J.J., Turnidge, M.A., Wai, D.H. et al. In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells. BMC Cancer 19, 1251 (2019). https://doi.org/10.1186/s12885-019-6464-9en_US
dc.identifier.issn1471-2407
dc.identifier.pmid31881855
dc.identifier.doi10.1186/s12885-019-6464-9
dc.identifier.urihttp://hdl.handle.net/10150/636781
dc.description.abstractGQC-05 treatment of KG-1a, CMK and TF-1 cells decreased cell viability and resulted in increased DNA damage and apoptosis. Additionally, treatment of KG-1a, CMK and TF-1 with GQC-05 resulted in decreased expression of MYC mRNA and protein, with a more pronounced effect in KG-1a cells. Combination drug screening identified the Bcl-2/Bcl-XL inhibitor Navitoclax as a compound that potentiated GQC-05 activity. Co-treatment with GQC-05 and Navitoclax showed a synergistic decrease in cell viability of AML cells as determined by Chou-Talalay analysis, and induced more DNA damage, apoptosis, and rapid cytotoxicity. The cytotoxicity induced by GQC-05 and Navitoclax was more potent than that of Navitoclax combined with either cytarabine or doxorubicin.en_US
dc.description.sponsorshipSharon D. Lund Foundation; University of Arizona COM-P Department of Child Health Mission Support; Phoenix Children's Hospital Foundation; St. Baldrick's Foundation; [5RO1CA177585]en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsCopyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.subjectAMLen_US
dc.subjectBcl-2en_US
dc.subjectBcl-XLen_US
dc.subjectG-quadruplexen_US
dc.subjectMYCen_US
dc.subjectNavitoclaxen_US
dc.titleIn vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cellsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Meden_US
dc.contributor.departmentUniv Arizona, Coll Pharmen_US
dc.identifier.journalBMC CANCERen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleBMC cancer
dc.source.volume19
dc.source.issue1
dc.source.beginpage1251
dc.source.endpage
refterms.dateFOA2020-01-29T22:54:15Z
dc.source.countryEngland


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