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    Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

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    Author
    González-Martín, Antonio
    Pothuri, Bhavana
    Vergote, Ignace
    DePont Christensen, René
    Graybill, Whitney
    Mirza, Mansoor R
    McCormick, Colleen
    Lorusso, Domenica
    Hoskins, Paul
    Freyer, Gilles
    Baumann, Klaus
    Jardon, Kris
    Redondo, Andrés
    Moore, Richard G
    Vulsteke, Christof
    O'Cearbhaill, Roisin E
    Lund, Bente
    Backes, Floor
    Barretina-Ginesta, Pilar
    Haggerty, Ashley F
    Rubio-Pérez, Maria J
    Shahin, Mark S
    Mangili, Giorgia
    Bradley, William H
    Bruchim, Ilan
    Sun, Kaiming
    Malinowska, Izabela A
    Li, Yong
    Gupta, Divya
    Monk, Bradley J
    Show allShow less
    Affiliation
    Univ Arizona, Coll Med, Arizona Oncol US Oncol Network
    Issue Date
    2019-09-28
    
    Metadata
    Show full item record
    Publisher
    MASSACHUSETTS MEDICAL SOC
    Citation
    González-Martín, A., Pothuri, B., Vergote, I., DePont Christensen, R., Graybill, W., Mirza, M. R., … Monk, B. J. (2019). Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer. New England Journal of Medicine, 381(25), 2391–2402. https://doi.org/10.1056/nejmoa1910962 ‌
    Journal
    NEW ENGLAND JOURNAL OF MEDICINE
    Rights
    Copyright © 2019 Massachusetts Medical Society.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Niraparib, an inhibitor of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP), has been associated with significantly increased progression-free survival among patients with recurrent ovarian cancer after platinum-based chemotherapy, regardless of the presence or absence of BRCA mutations. The efficacy of niraparib in patients with newly diagnosed advanced ovarian cancer after a response to first-line platinum-based chemotherapy is unknown.
    Note
    6 month embargo; published online: 28 September 2019
    ISSN
    0028-4793
    PubMed ID
    31562799
    DOI
    10.1056/NEJMoa1910962
    Version
    Final published version
    Sponsors
    GlaxoSmithKline
    ae974a485f413a2113503eed53cd6c53
    10.1056/NEJMoa1910962
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

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