Incidence Rate and Predictors of Globus Pallidus Necrosis after Charcoal Burning Suicide
AffiliationUniv Arizona, Dept Psychol
MetadataShow full item record
CitationKu, C.-H.; Huang, W.-H.; Hsu, C.-W.; Chen, Y.-C.; Hou, Y.-C.; Wang, I.-K.; Hong, H.-H.; Wang, Y.-L.; Weng, C.-H.; Yen, T.-H. Incidence Rate and Predictors of Globus Pallidus Necrosis after Charcoal Burning Suicide. Int. J. Environ. Res. Public Health 2019, 16, 4426.
RightsCopyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractObjective: This study examined predictors of globus pallidus necrosis as there was a paucity of literature of globus pallidus necrosis resulted from carbon monoxide poisoning after charcoal burning suicide. Methods: A total of 67 patients who had attempted charcoal burning suicide were recruited and stratified into two subgroups based on either presence (n = 40) or absence (n = 27) of globus pallidus necrosis. Demographic, clinical, laboratory, and radiographic data were obtained for cross-sectional analysis. All patients were followed to investigate the risks for mortality. Results: The patients aged 36.8 ± 11.1 years (67.2%) were male. Patients with globus pallidus necrosis were younger (p = 0.044) and had less hypertension (p = 0.015) than patients without globus pallidus necrosis. Furthermore, patients with globus pallidus necrosis suffered from severer medical complications, i.e., fever (p = 0.008), acute myocardial injury (p = 0.022), acute rhabdomyolysis (p = 0.022), and neuropsychiatric symptoms (p < 0.001) than patients without globus pallidus necrosis. Moreover, patients with globus pallidus necrosis received less hyperbaric oxygen therapy than without necrosis (p = 0.024). Two patients (3.0%) died on arrival. In a multivariable regression model, it was revealed that acute myocardial injury (odds ratio 4.6, confidence interval 1.1-18.9, p = 0.034) and neuropsychiatric symptoms (odds ratio 8.0, confidence interval 2.0-31.4, p = 0.003), decreased blood bicarbonate level (odds ratio 0.8, confidence interval 0.7-1.0, p = 0.032), and younger age (odds ratio 0.9, confidence interval 0.9-1.0, p = 0.038) were significant predictors for globus pallidus necrosis. Conclusion: Although patients who had attempted charcoal burning suicide had a low mortality rate (3.0%), globus pallidus necrosis was not uncommon (59.7%) in this population. Further studies are warranted.
NoteOpen access journal
VersionFinal published version
SponsorsChang Gung Memorial Hospital, Linkou, TaiwanChang Gung Memorial Hospital [CLRPG3D0016, CORPG5G0051]
- Alexithymia associated with bilateral globus pallidus lesions after carbon monoxide poisoning.
- Authors: Huang MF, Yeh YC, Tsang HY, Chen CS
- Issue date: 2010 Jun
- Acute Kidney Injury Predicts Mortality after Charcoal Burning Suicide.
- Authors: Chen YC, Tseng YC, Huang WH, Hsu CW, Weng CH, Liu SH, Yang HY, Chen KH, Chen HL, Fu JF, Lin WR, Wang IK, Yen TH
- Issue date: 2016 Jul 19
- Clinical predictors of psychiatric and medical morbidities of charcoal-burning suicide attempt in Hong Kong.
- Authors: Lee E, Leung CM
- Issue date: 2008 Nov-Dec
- Globus Pallidus Necrosis Unrelated to Carbon Monoxide Poisoning: Retrospective Analysis of 27 Cases of Basal Ganglia Necrosis.
- Authors: Yarid NA, Harruff RC
- Issue date: 2015 Nov
- Initial diffusion-weighted MRI and long-term neurologic outcomes in charcoal-burning carbon monoxide poisoning.
- Authors: Moon JM, Chun BJ, Baek BH, Hong YJ
- Issue date: 2018 Mar