Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions
AuthorTeixeira, Marcus M
Roe, Chandler C
Thompson, George R
Patané, José S L
Sahl, Jason W
Galgiani, John N
Litvintseva, Anastasia P
Matute, Daniel R
Barker, Bridget M
AffiliationUniv Arizona, Valley Fever Ctr Excellence, Coll Med
MetadataShow full item record
PublisherAMER SOC MICROBIOLOGY
CitationTeixeira MM, Alvarado P, Roe CC, Thompson GR, III, Patané JSL, Sahl JW, Keim P, Galgiani JN, Litvintseva AP, Matute DR, Barker BM. 2019. Population structure and genetic diversity among isolates of Coccidioides posadasii in Venezuela and surrounding regions. mBio 10:e01976-19. https://doi.org/10 .1128/mBio.01976-19.
RightsCopyright © 2019 Teixeira et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractCoccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions.IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.
NoteOpen access journal
VersionFinal published version
SponsorsNIH/NIAIDUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R21AI28536]; NIH/NIGMSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM121750]
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