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dc.contributor.authorStevenson, Glenn W
dc.contributor.authorGiuvelis, Denise
dc.contributor.authorCormier, James
dc.contributor.authorCone, Katherine
dc.contributor.authorAtherton, Phillip
dc.contributor.authorKrivitsky, Rebecca
dc.contributor.authorWarner, Emily
dc.contributor.authorSt Laurent, Brooke
dc.contributor.authorDutra, Julio
dc.contributor.authorBidlack, Jean M
dc.contributor.authorSzabò, Lajos
dc.contributor.authorPolt, Robin
dc.contributor.authorBilsky, Edward J
dc.date.accessioned2020-02-05T20:13:52Z
dc.date.available2020-02-05T20:13:52Z
dc.date.issued2020-01-07
dc.identifier.citationStevenson, G.W., Giuvelis, D., Cormier, J. et al. Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration. Psychopharmacology (2020). https://doi.org/10.1007/s00213-019-05449-zen_US
dc.identifier.issn0033-3158
dc.identifier.pmid31912192
dc.identifier.doi10.1007/s00213-019-05449-z
dc.identifier.urihttp://hdl.handle.net/10150/636964
dc.description.abstractBBI-11008 had a 78-fold greater affinity for the delta opioid receptor than the mu receptor, and there was no binding to the kappa opioid receptor. BBI-11008 (3.2-100; 10-32 mg kg-1, i.v.) and morphine (1-10; 1-3.2 mg kg-1, i.v.) produced antinociceptive and anti-allodynic effects in assays of acute thermal nociception and complete Freund's adjuvant (CFA)-induced inflammatory pain, with BBI-11008 being less potent than morphine in both assays. BBI-11008 (1-18 mg kg-1, i.v.) had similar efficacy to gabapentin (10-56 mg kg-1, i.v.) in a spinal nerve ligation (SNL) model of neuropathic pain. In the respiration assay, with increasing %CO2 exposure, BBI-11008 produced an initial increase (32 mg kg-1, s.c.) and then decrease (56 mg kg-1, s.c.) in minute volume (MV) whereas morphine (3.2-32 mg kg-1, s.c.) produced dose-dependent decreases in MV. In the drug self-administration procedure, BBI-11008 did not maintain self-administration at any dose tested.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.rightsCopyright © Springer-Verlag GmbH Germany, part of Springer Nature 2020.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectAntiallodyniaen_US
dc.subjectAntinociceptionen_US
dc.subjectDelta opioid receptoren_US
dc.subjectDelta/mu opioid agonisten_US
dc.subjectDrug self-administrationen_US
dc.subjectGI transiten_US
dc.subjectGlycopeptideen_US
dc.subjectMiceen_US
dc.subjectRatsen_US
dc.subjectRespiratory depressionen_US
dc.titleBehavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administrationen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Chem & Biochemen_US
dc.identifier.journalPSYCHOPHARMACOLOGYen_US
dc.description.note12 month embargo; published online: 7 January 2020en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitlePsychopharmacology
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryGermany


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