Association of UCP1, UCP2 and UCP3 gene polymorphisms with cardiovascular disease risk factors in European adolescents: the HELENA study
AuthorPascual-Gamarra, Jose M
Salazar-Tortosa, Diego F
Rupérez, Azahara I
Moreno, Luis A
Castillo, Manuel J
R Ruiz, Jonatan
AffiliationUniv Arizona, Dept Ecol & Evolutionary Biol
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationPascual-Gamarra, J.M., Salazar-Tortosa, D.F., Labayen, I. et al. Association of UCP1, UCP2 and UCP3 gene polymorphisms with cardiovascular disease risk factors in European adolescents: the HELENA study. Pediatr Res (2020). https://doi.org/10.1038/s41390-019-0735-7
RightsCopyright © International Pediatric Research Foundation, Inc. 2020
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBackground Cardiovascular diseases (CVDs) are responsible for 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. The aim of this study was to examine the association of UCP1, UCP2 and UCP3 gene polymorphisms with CVD risk factors in European adolescents. Method A cross-sectional study that involves 1.057 European adolescents (12-18 years old) from the HELENA study. A total of 18 polymorphisms of UCP1, UCP2 and UCP3 genes were genotyped. We measured serum total cholesterol, high-density lipoprotein,low-density lipoprotein, ApoA1, ApoB, leptin, triglycerides, glucose, insulin and blood pressure, and calculated HOMA (homeostatic model assessment), Quantitative Insulin Sensitivity Check Index (QUICKI) and a CVD risk score. Results The G allele of UCP2 rs2735572 and T allele of UCP2 rs17132534 were associated with higher diastolic blood pressure (P = 0.001; false discovery rate [FDR] = 0.009 and P = 8e-04; FDR = 0.009, respectively). We observed that the AATAG haplotype of UCP1 was associated with higher serum ApoB/ApoA1 (P = 0.008; FDR = 0.031) and ApoB levels (P = 0.008; FDR = 0.031). Moreover, the ACC haplotype of UCP3 was associated with a higher CVD risk score (P = 0.0036; FDR = 0.01). Conclusions Two UCP2 polymorphisms and haplotypes of UCP1 and UCP3 were associated with CVD risk factors. These findings suggest that UCPs may have a role in the development of CVD already in adolescents.
Note6 month embargo; published online: 3 January 2020
VersionFinal accepted manuscript
- Association between UCP1, UCP2, and UCP3 gene polymorphisms with markers of adiposity in European adolescents: The HELENA study.
- Authors: Pascual-Gamarra JM, Salazar-Tortosa D, Martinez-Tellez B, Labayen I, Rupérez AI, Censi L, Manios Y, Nova E, Gesteiro E, Moreno LA, Meirhaeghe A, Ruiz JR
- Issue date: 2019 Jun
- Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T polymorphisms and susceptibility to type 2 diabetes mellitus: case-control study and meta-analysis.
- Authors: de Souza BM, Brondani LA, Bouças AP, Sortica DA, Kramer CK, Canani LH, Leitão CB, Crispim D
- Issue date: 2013
- Modulation of uncoupling protein 2 and uncoupling protein 3: regulation by denervation, leptin and retinoic acid treatment.
- Authors: Scarpace PJ, Matheny M, Moore RL, Kumar MV
- Issue date: 2000 Mar
- Association between UCP polymorphisms and adipokines with obesity in Mexican adolescents.
- Authors: Sámano R, Huesca-Gómez C, López-Marure R, Hernández-Cabrera AK, Rodríguez-Ventura A, Tolentino M, Morales RM, Gamboa R
- Issue date: 2018 Apr 25
- UCP2 A55V variant is associated with obesity and related phenotypes in an aboriginal community in Taiwan.
- Authors: Wang TN, Huang MC, Lin HL, Hsiang CH, Ko AM, Chang WT, Ko YC
- Issue date: 2007 Nov