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dc.contributor.advisorRyan, Lee
dc.contributor.authorGregolynskyj, Amanda Brittany
dc.creatorGregolynskyj, Amanda Brittany
dc.date.accessioned2020-02-13T03:03:04Z
dc.date.available2020-02-13T03:03:04Z
dc.date.issued2019-12
dc.identifier.urihttp://hdl.handle.net/10150/637028
dc.description.abstractThe present study of 64 older adults (60-80 years) investigated the impact of depressive symptoms and cardiovascular risk factors (CVRFs) on gray matter volumes. Participants’ depressive symptoms were measured using the Geriatric Depression Scale (GDS) and their CVRF status was determined based on the presence of obesity and hypertension. Participants underwent neuroimaging and gray matter volumes were compared using voxel-based morphometry. Higher GDS scores (greater number of symptoms endorsed) were associated with lower gray matter volumes in the right superior temporal lobe, left inferior orbitofrontal cortex, right superior frontal cortex, left insula, and bilateral angular gyri. CVRFs were associated with larger gray matter volumes in mostly posterior regions, ranging from the middle frontal gyrus to the occipital lobe. Individuals with both CVRFs present had smaller volumes in the right lingual gyrus with higher GDS scores. In contrast, higher GDS scores were associated with larger gray matter volumes in the right parieto-occipital region among individuals who exhibited only one CVRF. Our results show the complex interactive roles of depressive symptoms and CVRFs on gray matter volumes and support the need for future research investigating the effects of mental and physical health on the brain.en_US
dc.language.isoenen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.titleTHE EFFECTS OF CARDIOVASCULAR RISK FACTORS AND MILD DEPRESSIVE SYMPTOMS ON GRAY MATTER VOLUME AMONG COGNITIVELY HEALTHY OLDER ADULTSen_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplineNeuroscience and Cognitive Science
thesis.degree.nameB.S.en_US
refterms.dateFOA2020-02-13T03:03:05Z


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