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    ARE THERE NICOTINIC ACETYLCHOLINE RECEPTORS ON PHRENIC MOTOR NEURONS?

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    Honors Thesis
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    Author
    Henderson, Kimberly
    Issue Date
    2019-08
    Keywords
    Nicotine
    nAChR
    artificial Cerebrospinal Fluid (aCSF)
    Phrenic Nerve
    Phrenic Motor Neurons
    Brainstem-Spinal Cord Preparation
    Advisor
    Fregosi, Ralph F.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Nicotinic acetylcholine receptors (nAChRs) are expressed throughout the central nervous system, including on neuron populations that control breathing. The specific locations of nAChRs on respiratory related neurons are relatively unknown and their presence on phrenic motor neurons (PMNs) could indicate a point at which developmental nicotine exposure may impact breathing. We hypothesize that application of nicotine to the PMNs will elicit changes in amplitude and area of respiratory motor bursting recorded from cervical 3-5 ventral roots due to the presence of nAChRs on PMNs. A brainstem spinal cord split-bath preparation was used to separately perfuse brainstem and spinal cord chambers with artificial cerebrospinal fluid (aCSF), and nicotinic aCSF was added to the spinal cord chamber. Burst amplitude and area under the curve were measured at baseline and during application of three different nicotine concentrations (400nM, 4M, 40M). Our results show that while 400nM nicotinic aCSF did not significantly affect the amplitude or area of bursts, both 4M and 40  nicotinic aCSF caused an initial increase in amplitude and area of the bursts, indicating nAChR activation, followed by a decrease in these parameters, indicating nAChR desensitization. These findings indicate the presence of nAChR on PMNs or neurons that synapse with PMNs.
    Type
    text
    Electronic Thesis
    Degree Name
    B.S.
    Degree Level
    bachelors
    Degree Program
    Honors College
    Neuroscience and Cognitive Science
    Degree Grantor
    University of Arizona
    Collections
    Honors Theses

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