• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    DNA Methylation Across the Serotonin Transporter Gene Following Marital Separation: A Pilot Study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Sbarra_MethySert_Final Accepted.pdf
    Size:
    210.0Kb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
    Download
    Author
    Sbarra, David A
    Cook, Chelsea C
    Hasselmo, Karen
    Noon, Muhammad S
    Mehl, Matthias R
    Affiliation
    Univ Arizona, Data Sci Inst
    Univ Arizona, Dept Psychol
    Issue Date
    2019-12-12
    Keywords
    Coping
    DNA methylation
    Divorce
    Genomics
    Marital separation
    Stress
    
    Metadata
    Show full item record
    Publisher
    OXFORD UNIV PRESS INC
    Citation
    Sbarra, D. A., Cook, C. C., Hasselmo, K., Noon, M. S., & Mehl, M. R. (2019). DNA Methylation Across the Serotonin Transporter Gene Following Marital Separation: A Pilot Study. Annals of Behavioral Medicine, 53(12), 1081-1087.
    Journal
    ANNALS OF BEHAVIORAL MEDICINE
    Rights
    Copyright © Society of Behavioral Medicine 2019. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background Marital separation and divorce are stressful life transitions associated with increased risk for a range of poor mental and physical health outcomes. A key task for research in this area is to identify individual differences that may index risk for these adverse outcomes. Purpose To examine the association between DNA methylation across the serotonin transporter gene (SLC6A4) and self-reported emotional distress following marital separation. Methods Genomic DNA methylation (from buffy coat fractions of whole blood) was quantified in a sample of 47 adults following a recent marital separation; concurrent with the blood draw, participants completed questionnaires on their psychological adjustment to the separation experience. Results Relatively greater methylation of SLC6A4 was associated with less subjective separation-related psychological distress, and this association held after accounting for participants' age, length of the relationship, time since the separation, and SLC6A4 genotype, b = -211.99, SE = 94.91, p = .03, 95% CI: -402.22, -25.21. Significantly stronger negative associations were observed between methylation and psychological adjustment among participants who had more recently separated from their former partner. Conclusions Although results derived from small samples must be considered preliminary and hypothesis generating, the current study raises new questions about the role of DNA methylation and psychosocial adaptation to stressful life events such as divorce, and the findings can inform future studies in this research area.
    Note
    12 month embargo; published online: 12 December 2019
    ISSN
    0883-6612
    PubMed ID
    31053862
    DOI
    10.1093/abm/kaz013
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1093/abm/kaz013
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.
    • Authors: Hasselmo K, Sbarra DA, O'Connor MF, Moreno FA
    • Issue date: 2015 Jun
    • Adverse life events and allele-specific methylation of the serotonin transporter gene (SLC6A4) in adolescents: the TRAILS study.
    • Authors: van der Knaap LJ, Riese H, Hudziak JJ, Verbiest MM, Verhulst FC, Oldehinkel AJ, van Oort FV
    • Issue date: 2015 Apr
    • An internet-based self-help intervention for older adults after marital bereavement, separation or divorce: study protocol for a randomized controlled trial.
    • Authors: Brodbeck J, Berger T, Znoj HJ
    • Issue date: 2017 Jan 13
    • Marital dissolution and blood pressure reactivity: evidence for the specificity of emotional intrusion-hyperarousal and task-rated emotional difficulty.
    • Authors: Sbarra DA, Law RW, Lee LA, Mason AE
    • Issue date: 2009 Jun
    • Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression.
    • Authors: Lam D, Ancelin ML, Ritchie K, Freak-Poli R, Saffery R, Ryan J
    • Issue date: 2018 Sep 4
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.