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dc.contributor.authorArbona, Nichole
dc.contributor.authorButkiewicz, Christine
dc.contributor.authorKeyes, Minta
dc.contributor.authorShubitz, Lisa
dc.date.accessioned2020-02-21T17:27:09Z
dc.date.available2020-02-21T17:27:09Z
dc.date.issued2020-02
dc.identifier.citationArbona N, Butkiewicz CD, Keyes M, and Shubitz LF. Clinical features of cats diagnosed with coccidioidomycosis in Arizona, 2004 - 2018. Journal of Feline Medicine and Surgery. 2020. 22(2): 129-137.en_US
dc.identifier.issn1098-612X
dc.identifier.pmid30784342
dc.identifier.doi10.1177/1098612X19829910
dc.identifier.urihttp://hdl.handle.net/10150/637065
dc.description.abstractObjectives: The goal of this study was to describe the clinical presentation, diagnosis and treatment of coccidioidomycosis in cats residing in a region endemic for Coccidioides species. Methods: A retrospective review of records was performed at both primary and tertiary care veterinary practices in Tucson and Phoenix, AZ. Data collected included signalment, clinical signs, physical exam findings, diagnostic test results, treatment and outcome. Results: Fifty-one feline cases were identified from six different veterinary hospitals. Cats presented with clinical signs and laboratory abnormalities similar to what has been seen in dogs, including respiratory illness (20/51), neutrophilia (24/31), monocytosis (17/31), and hyperglobulinemia (16/30). However, cats at diagnosis were typically significantly ill, with 31/51 having disseminated infection, most commonly to the skin (n=22). Additionally, 43/44 cats that had serum antibody tests performed were positive, and median titer at diagnosis was 1:32 (range 1:4 – ≥1:256). Serum antibody titers reduced significantly (P ≤0.001) in cats that responded to treatment compared with cats that did not clinically improve. 40/46 cats that were treated with oral flucaonzole responded and did not require additional therapy. Fourteen cats developed recurrent disease and all but 1 had antifungal therapy successfully reinstituted. Conclusions and relevance: Coccidioidomycosis is a disease of concern for cats residing in the region endemic for Coccidoides spp. Disease is most often disseminated at the time of diagnosis, possibly due to delays in presentation for care and recognition of the infection. Suspicion of disease, serum chemistries, blood cell counts, presence of antibody, and imaging aid in diagnosis of coccidioidomycosis in cats. Serum antibody reduction during treatment frequently correlated with an adequate response to medication. Consideration of coccidioidomycosis as a cause of illness will lead to earlier diagnosis and potentially better treatment outcomes in cats.  en_US
dc.language.isoenen_US
dc.publisherSAGEen_US
dc.rights© The Author(s) 2019en_US
dc.subjectCoccidioidesen_US
dc.subjectcoccidioidomycosisen_US
dc.subjectcommunicable diseasesen_US
dc.subjectepidemiologyen_US
dc.subjectmycosesen_US
dc.subjectveterinaryen_US
dc.titleClinical features of cats diagnosed with coccidioidomycosis in Arizona, 2004 - 2018en_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Valley Fever Ctr Excellenceen_US
dc.identifier.journalJournal of Feline Medicine and Surgeryen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
refterms.dateFOA2020-02-21T17:27:10Z


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