Gastric Cardia Adenocarcinoma with Metastasis to the Scalp: A Case Report
AffiliationUniv Arizona, Coll Med, Dermatol
Univ Arizona, Coll Med, Internal Med
Univ Arizona, Ctr Canc, Oncol
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CitationMenghani S V, Barbosa A, Sagerman P, et al. (January 27, 2020) Gastric Cardia Adenocarcinoma with Metastasis to the Scalp: A Case Report. Cureus 12(1): e6781. doi:10.7759/cureus.6781
RightsCopyright © 2020 Menghani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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AbstractCutaneous metastasis is a rare manifestation of advanced gastrointestinal (GI) cancers. Gastric adenocarcinoma rarely presents with cutaneous metastasis, as cutaneous manifestations occur in less than 1% of upper GI tract malignancies. Here, we present the case of a patient with advanced gastric cardia adenocarcinoma with metastasis to the right occipital region of the scalp. Following shave biopsy, the immunohistochemistry (IHC) and molecular profile of the scalp lesion were analyzed, both of which confirmed metastasis and guided the treatment approach. The lesion demonstrated programmed death ligand-1 (PD-L1), an immune checkpoint protein, positivity by IHC, which led to the recommendation for treatment with immunotherapy as per the National Comprehensive Cancer Network (NCCN) guidelines. Clinicians should conduct dermatologic examinations in patients with a history of gastric cancer or who are currently undergoing chemotherapy for gastric cancer in order to monitor for disease progression or metastatic lesions. The aim of this report is to increase awareness of scalp metastasis as an indicator of advanced internal visceral carcinoma for earlier diagnosis and improved management of the condition.
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