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dc.contributor.authorShimasaki, Craig
dc.contributor.authorFrye, Richard E
dc.contributor.authorTrifiletti, Rosario
dc.contributor.authorCooperstock, Michael
dc.contributor.authorKaplan, Gary
dc.contributor.authorMelamed, Isaac
dc.contributor.authorGreenberg, Rosalie
dc.contributor.authorKatz, Amiram
dc.contributor.authorFier, Eric
dc.contributor.authorKem, David
dc.contributor.authorTraver, David
dc.contributor.authorDempsey, Tania
dc.contributor.authorLatimer, M Elizabeth
dc.contributor.authorCross, Amy
dc.contributor.authorDunn, Joshua P
dc.contributor.authorBentley, Rebecca
dc.contributor.authorAlvarez, Kathy
dc.contributor.authorReim, Sean
dc.contributor.authorAppleman, James
dc.date.accessioned2020-03-10T16:30:06Z
dc.date.available2020-03-10T16:30:06Z
dc.date.issued2020-02-15
dc.identifier.citationShimasaki, C., Frye, R. E., Trifiletti, R., Cooperstock, M., Kaplan, G., Melamed, I., ... & Traver, D. (2020). Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms. Journal of Neuroimmunology, 339, 577138.en_US
dc.identifier.issn0165-5728
dc.identifier.pmid31884258
dc.identifier.doi10.1016/j.jneuroim.2019.577138
dc.identifier.urihttp://hdl.handle.net/10150/637677
dc.description.abstractComparison of pre- and post-treatment status revealed that the Cunningham Panel results correlated with changes in patient's neuropsychiatric symptoms. Based upon the change in the number of positive tests, the overall accuracy was 86%, the sensitivity and specificity were 88% and 83% respectively, and the Area Under the Curve (AUC) was 93.4%. When evaluated by changes in autoantibody levels, we observed an overall accuracy of 90%, a sensitivity of 88%, a specificity of 92% and an AUC of 95.7%. Assay reproducibility for the calcium/calmodulin-dependent protein kinase II (CaMKII) revealed a correlation coefficient of 0.90 (p < 1.67 × 10-6) and the ELISA assays demonstrated test-retest reproducibility comparable with other ELISA assays.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.rights© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en_US
dc.subjectAntineuronal antibodiesen_US
dc.subjectAutoimmune encephalopathyen_US
dc.subjectBasal ganglia encephalitisen_US
dc.subjectBasal ganglia encephalopathyen_US
dc.subjectCaMKIIen_US
dc.subjectCunningham Panelen_US
dc.subjectPANDAS, PANSen_US
dc.titleEvaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptomsen_US
dc.typeArticleen_US
dc.identifier.eissn1872-8421
dc.contributor.departmentUniv Arizona, Phoenix Childrens Hosp, Barrow Neurol Inst, Dept Child Hlth,Coll Med Phoenixen_US
dc.identifier.journalJOURNAL OF NEUROIMMUNOLOGYen_US
dc.description.noteOpen access articleen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleJournal of neuroimmunology
dc.source.volume339
dc.source.beginpage577138
dc.source.endpage
refterms.dateFOA2020-03-10T16:30:07Z
dc.source.countryNetherlands


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