Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?
AffiliationUniv Arizona, Dept Urol
Univ Arizona, Dept Epidemiol & Biostat
Renal pelvis urothelial carcinoma
Upper tract urothelial carcinoma
Ureteral urothelial carcinoma
MetadataShow full item record
PublisherCIG MEDIA GROUP, LP
CitationLwin, A. A., Hsu, C. H., & Chipollini, J. (2020). Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?. Clinical Genitourinary Cancer, 18(1), 45-49.
JournalCLINICAL GENITOURINARY CANCER
RightsCopyright © 2019 Elsevier Inc. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractThere has been a scarcity of data on outcomes of upper tract urothelial carcinoma. We queried a large cancer registry and found a strong association between survival and location of tumor. Patients with ureteral urothelial carcinoma were found to be treated with less radical surgery and to have worse survival than those with renal pelvis urothelial carcinoma. These patients may suffer from poor initial staging and suboptimal treatments. Background: There is a paucity of data on outcomes of upper tract urothelial carcinoma (UTUC) arising from the renal pelvis (RPUC) versus UTUC arising from the ureter (UUC). The published literature is conflicting, and there is no consensus on patient prognosis based on disease location. The aim of this study is to compare clinical and survival outcomes based on location of primary tumor using a large national registry. Materials and Methods: The National Cancer Database was queried from 2010 to 2016 for patients with localized (cN0M0) UTUC. Patients were stratified based on location of tumor. Survival analysis was performed using Cox proportional hazard regression and inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier curves. We also performed exploratory analyses based on tumor stage. Results: We identified 11,922 patients who underwent surgical treatment. The median follow-up was 32.1 months. Patients with RPUC presented with higher tumor stage and grade. Patients with UUC were treated with less radical nephroureterectomy (56.4% vs. 84.3%; P < .01). IPTW-adjusted Kaplan-Meier curves demonstrated higher median overall survival for RPUC versus UUC (71.1 vs. 66.8 months, respectively; P = .01). This benefit was consistent across tumor stage subgroups, reaching statistical significance in patients with T1 disease. On multivariable analysis, ureteral location of tumor was a predictor of worse survival. Conclusion: Patients with UUC were found to be treated with less radical surgery and to have worse survival than those with RPUC. These patients may suffer from poor initial staging and suboptimal treatments. Further studies are needed to evaluate potential biological differences of UTUC based on tumor location. (C) 2019 Elsevier Inc. All rights reserved.
Note12 month embargo; published online: 6 November 2019
VersionFinal accepted manuscript
- Transitional cell carcinomas of the renal pelvis and the ureter: comparative demographic characteristics, pathological grade and stage and 5-year survival in a Taiwanese population.
- Authors: Tan LB, Chang LL, Cheng KI, Huang CH, Kwan AL
- Issue date: 2009 Feb
- The effect of tumor location on prognosis in patients treated with radical nephroureterectomy at Memorial Sloan-Kettering Cancer Center.
- Authors: Favaretto RL, Shariat SF, Chade DC, Godoy G, Adamy A, Kaag M, Bochner BH, Coleman J, Dalbagni G
- Issue date: 2010 Oct
- Impact of micropapillary histological variant on survival after radical nephroureterectomy for upper tract urothelial carcinoma.
- Authors: Masson-Lecomte A, Colin P, Bozzini G, Nison L, de La Taille A, Comperat E, Zerbib M, Rozet F, Cathelineau X, Valeri A, Ruffion A, Guy L, Droupy S, Cussenot O, Rouprêt M
- Issue date: 2014 Apr
- Rates of lymph node invasion and their impact on cancer specific mortality in upper urinary tract urothelial carcinoma.
- Authors: Nazzani S, Mazzone E, Preisser F, Tian Z, Mistretta FA, Shariat SF, Montanari E, Acquati P, Briganti A, Saad F, Carmignani L, Karakiewicz PI
- Issue date: 2019 Jul
- Pattern and risk factors of local recurrence after nephroureterectomy for upper tract urothelial carcinoma.
- Authors: Li X, Cui M, Gu X, Fang D, Li H, Qin S, Yang K, Zhu T, Li X, Zhou L, Gao XS, Wang D
- Issue date: 2020 May 30