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dc.contributor.authorLwin, Aye A
dc.contributor.authorHsu, Chiu-Hsieh
dc.contributor.authorChipollini, Juan
dc.date.accessioned2020-03-11T18:39:45Z
dc.date.available2020-03-11T18:39:45Z
dc.date.issued2020-02
dc.identifier.citationLwin, A. A., Hsu, C. H., & Chipollini, J. (2020). Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?. Clinical Genitourinary Cancer, 18(1), 45-49.en_US
dc.identifier.issn1558-7673
dc.identifier.pmid31786118
dc.identifier.doi10.1016/j.clgc.2019.10.023
dc.identifier.urihttp://hdl.handle.net/10150/637695
dc.description.abstractThere has been a scarcity of data on outcomes of upper tract urothelial carcinoma. We queried a large cancer registry and found a strong association between survival and location of tumor. Patients with ureteral urothelial carcinoma were found to be treated with less radical surgery and to have worse survival than those with renal pelvis urothelial carcinoma. These patients may suffer from poor initial staging and suboptimal treatments. Background: There is a paucity of data on outcomes of upper tract urothelial carcinoma (UTUC) arising from the renal pelvis (RPUC) versus UTUC arising from the ureter (UUC). The published literature is conflicting, and there is no consensus on patient prognosis based on disease location. The aim of this study is to compare clinical and survival outcomes based on location of primary tumor using a large national registry. Materials and Methods: The National Cancer Database was queried from 2010 to 2016 for patients with localized (cN0M0) UTUC. Patients were stratified based on location of tumor. Survival analysis was performed using Cox proportional hazard regression and inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier curves. We also performed exploratory analyses based on tumor stage. Results: We identified 11,922 patients who underwent surgical treatment. The median follow-up was 32.1 months. Patients with RPUC presented with higher tumor stage and grade. Patients with UUC were treated with less radical nephroureterectomy (56.4% vs. 84.3%; P < .01). IPTW-adjusted Kaplan-Meier curves demonstrated higher median overall survival for RPUC versus UUC (71.1 vs. 66.8 months, respectively; P = .01). This benefit was consistent across tumor stage subgroups, reaching statistical significance in patients with T1 disease. On multivariable analysis, ureteral location of tumor was a predictor of worse survival. Conclusion: Patients with UUC were found to be treated with less radical surgery and to have worse survival than those with RPUC. These patients may suffer from poor initial staging and suboptimal treatments. Further studies are needed to evaluate potential biological differences of UTUC based on tumor location. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherCIG MEDIA GROUP, LPen_US
dc.rightsCopyright © 2019 Elsevier Inc. All rights reserved.en_US
dc.subjectOutcomesen_US
dc.subjectRenal pelvis urothelial carcinomaen_US
dc.subjectSurvivalen_US
dc.subjectUpper tract urothelial carcinomaen_US
dc.subjectUreteral urothelial carcinomaen_US
dc.titleUrothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?en_US
dc.typeArticleen_US
dc.identifier.eissn1938-0682
dc.contributor.departmentUniv Arizona, Dept Urolen_US
dc.contributor.departmentUniv Arizona, Dept Epidemiol & Biostaten_US
dc.identifier.journalCLINICAL GENITOURINARY CANCERen_US
dc.description.note12 month embargo; published online: 6 November 2019en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleClinical genitourinary cancer
dc.source.volume18
dc.source.issue1
dc.source.beginpage45
dc.source.endpage49.e1
dc.source.countryUnited States


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