Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Reiman, Eric M

dc.contributor.author	Reiman, Eric M
dc.date.accessioned	2020-03-18T20:53:06Z
dc.date.available	2020-03-18T20:53:06Z
dc.date.issued	2020-02-03
dc.identifier.citation	Reiman, E.M., Arboleda-Velasquez, J.F., Quiroz, Y.T. et al. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun 11, 667 (2020). https://doi.org/10.1038/s41467-019-14279-8	en_US
dc.identifier.issn	2041-1723
dc.identifier.pmid	32015339
dc.identifier.doi	10.1038/s41467-019-14279-8
dc.identifier.uri	http://hdl.handle.net/10150/637741
dc.description.abstract	Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer's dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer's dementia cases and controls. APOE2/2 was associated with a low Alzheimer's dementia odds ratios compared to APOE2/3 and 3/3, and an exceptionally low odds ratio compared to APOE4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and controls. Finding and targeting the factors by which APOE and its variants influence Alzheimer's disease could have a major impact on the understanding, treatment and prevention of the disease.	en_US
dc.language.iso	en	en_US
dc.publisher	NATURE PUBLISHING GROUP	en_US
dc.rights	Copyright © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.	en_US
dc.title	Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study	en_US
dc.type	Article	en_US
dc.contributor.department	Univ Arizona	en_US
dc.identifier.journal	NATURE COMMUNICATIONS	en_US
dc.description.note	Open access journal	en_US
dc.description.collectioninformation	This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.	en_US
dc.eprint.version	Final published version	en_US
refterms.dateFOA	2020-03-18T20:53:07Z