Serum matrix metalloproteinase-9 in children exposed to arsenic from playground dust at elementary schools in Hermosillo, Sonora, Mexico
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Final Accepted Manuscript
Author
García-Rico, LeticiaMeza-Figueroa, Diana
Beamer, Paloma I
Burgess, Jefferey L
O'Rourke, Mary K
Lantz, Clark R
Furlong, Melissa
Martinez-Cinco, Marco
Mondaca-Fernandez, Iram
Balderas-Cortes, Jose J
Meza-Montenegro, Maria M
Affiliation
Univ Arizona, Mel & Enid Zuckerman Coll Publ HlthUniv Arizona, Dept Cellular & Mol Med
Issue Date
2020-02
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García-Rico, L., Meza-Figueroa, D., Beamer, P.I. et al. Serum matrix metalloproteinase-9 in children exposed to arsenic from playground dust at elementary schools in Hermosillo, Sonora, Mexico. Environ Geochem Health 42, 499–511 (2020). https://doi.org/10.1007/s10653-019-00384-6Rights
© Springer Nature B.V. 2019.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Arsenic exposure in adults has been associated with increased serum matrix metalloproteinase-9 (MMP-9), a biomarker which is associated with chronic respiratory disease, lung inflammation, cardiovascular disease and cancer. The objective of this study was to evaluate the association between serum MMP-9 levels in children, urinary arsenic, arsenic chronic daily intake (CDI) and arsenic exposure from playground dust. This cross-sectional study examined 127 children from five elementary schools, in Hermosillo, Sonora, Mexico. Arsenic was analyzed in the dust using a portable X-ray fluorescence (XRF) analyzer. Total urinary arsenic was determined by inductively coupled plasma/optical emission spectrometry. Serum was analyzed for MMP-9 using ELISA. Arsenic levels in playground dust averaged 16.9 +/- 4.6 mg/kg. Urinary arsenic averaged 34.9 +/- 17.1 mu g/L. Arsenic concentration in playground dust was positively associated with serum MMP-9 levels in crude analyses and after adjustment (P < 0.01), MMP-9 and CDI were positively associated only after adjustment (P < 0.01), and no association was found between MMP-9 and urinary arsenic. In conclusion, our study showed an association in children between serum MMP-9 levels and playground dust arsenic concentrations. Therefore, exposure to arsenic in dust where children spend significant time may manifest toxic effects.Note
12 month embargo; published online: 1 August 2019ISSN
0269-4042EISSN
1573-2983PubMed ID
31372863Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1007/s10653-019-00384-6
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