Effect of exogenous progesterone administration on cigarette smoking-related symptomology in oral contraceptive users who smoke
Allen, Alicia M
AffiliationUniv Arizona, Dept Family & Community Med
MetadataShow full item record
PublisherPERGAMON-ELSEVIER SCIENCE LTD
CitationHarrison, K., Petersen, A., Tosun, N., Crist, K., Allen, A. M., & Allene, S. (2020). Effect of exogenous progesterone administration on cigarette smoking-related symptomology in oral contraceptive users who smoke. Addictive behaviors, 102, 106148. doi:10.1016/j.addbeh.2019.106148
RightsCopyright © 2019. Published by Elsevier Ltd.
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AbstractCigarette smoking-related symptomatology (e.g., craving; SRS) is linked to relapse after a quit attempt. SRS varies by menstrual phase, possibly due to variations in sex hormones (e.g., progesterone), though much of the research to-date has relied on observations from the menstrual cycle acting as a proxy for hormone levels. The goal of this study was to examine the effect of exogenous progesterone on SRS during ad libitum smoking and following overnight abstinence. Oral contraceptive users who smoked completed two 9-day crossover testing periods (7 days of ad libitum smoking and 2 days following overnight abstinence) while taking double-blind active/placebo exogenous progesterone. Participants completed questionnaires to measure SRS. The effect of exogenous progesterone and endogenous hormones (progesterone, estradiol, and progesterone-to-estradiol [P/E2] ratio) on SRS was assessed with paired t-tests and linear mixed effect models. Participants (n = 53) were, on average, 24 years old and smoked 11 cigarettes per day. During ad libitum smoking, a doubling of the P/E2 ratio was associated with 0.09 points lower anticipated relief from negative affect (95% confidence interval [CI]: 0.03-0.15 points lower; p = 0.008) and 0.11 points lower psychological reward (95% CI: 0.03-0.18 points lower; p = 0.006). After correction for multiple testing, these associations were not statistically significant: anticipated relief from negative effect (p = 0.10) and psychological reward (p = 0.09). No other significant associations were observed. Although substantial previous literature indicates that progesterone influences SRS, exogenous progesterone administration did not alter SRS here. Additional research is needed to elucidate alternative mechanisms involved in menstrual phase effects on SRS.
Note24 month embargo; published online: 19 October 2019
VersionFinal accepted manuscript
- Smoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence.
- Authors: Allen S, Harrison K, Petersen A, Goodson J
- Issue date: 2019 Aug 1
- Effect of exogenous progesterone administration on smoking topography.
- Authors: Allen A, Petersen A, Harrison K, Nair U, Allen S
- Issue date: 2020 Jul 22
- Postpartum Changes in Mood and Smoking-Related Symptomatology: An Ecological Momentary Assessment Investigation.
- Authors: Allen A, Tosun N, Carlson S, Allen S
- Issue date: 2018 May 3
- Subjective response to intranasal nicotine administration in oral contraceptive users and naturally-cycling women.
- Authors: Allen AM, Friedrichsen SC, Petersen N, Allen SS
- Issue date: 2019 Nov
- Cardiovascular and mood responses to quantified doses of cigarette smoke in oral contraceptive users and nonusers.
- Authors: Masson CL, Gilbert DG
- Issue date: 1999 Dec