Retrospective Analysis of Low-Molecular-Weight Heparin and Unfractionated Heparin in Pediatric Trauma Patients: A Comparative Analysis
Name:
Manuscript_(FINAL_REVISED).pdf
Size:
225.0Kb
Format:
PDF
Description:
Final Accepted Manuscript
Author
Culbert, Michael HunterHamidi, Mohammad
Zeeshan, Muhammad
Hanna, Kamil
Romero, Andrew
Joseph, Bellal
O'Keeffe, Terence
Affiliation
Univ Arizona, Coll Med, Dept SurgIssue Date
2020-05
Metadata
Show full item recordPublisher
ACADEMIC PRESS INC ELSEVIER SCIENCECitation
Culbert, M. H., Hamidi, M., Zeeshan, M., Hanna, K., Romero, A., Joseph, B., & O'Keeffe, T. (2020). Retrospective Analysis of LMWH and UFH in Pediatric Trauma Patients: A Comparative Analysis. Journal of Surgical Research, 249, 121-129. https://doi.org/10.1016/j.jss.2019.11.019Journal
JOURNAL OF SURGICAL RESEARCHRights
Copyright © 2019 Elsevier Inc. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background: Chemoprophylaxis with either unfractionated heparin (UFH) or Low-Molecular-Weight Heparin (LMWH) are recommended to prevent Venous Thromboembolism (VTE) after trauma. Experimental work has shown beneficial effects of LMWH in animal models, but it is unknown if similar effects exist in humans. We hypothesized that treatment with LMWH is associated with a survival benefit when compared to UFH. Methods: We performed a retrospective analysis of our level I trauma center database from January 2009 to June 2018. Pediatric patients (age < 18) were included if they received either LMWH or UFH during their stay. Outcome measures included mortality, VTE complications, and hospital length of stay (HLOS). Results: A total of 354 patients were included. Patients who received LMWH had lower mortality compared to those who received UFH. After multivariate logistic regression, LMWH was still independently associated with improved survival. No association was found between LMWH and UFH regarding deep vein thrombosis (DVT) or pulmonary embolism (PE) rates. No association was found between LMWH with HLOS. Conclusions: LMWH was associated with improved survival compared to UFH in our pediatric trauma patients. This was independent of injury severity or VTE complications. Further studies are required to understand better the mechanisms by which LMWH improves survival. (C) 2019 Elsevier Inc. All rights reserved.Note
12 month embargo; published online: 10 January 2020ISSN
0022-4804EISSN
1095-8673PubMed ID
31931398Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1016/j.jss.2019.11.019
Scopus Count
Collections
Related articles
- Unfractionated heparin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in trauma.
- Authors: Jacobs BN, Cain-Nielsen AH, Jakubus JL, Mikhail JN, Fath JJ, Regenbogen SE, Hemmila MR
- Issue date: 2017 Jul
- Determining the impact of culture on venous thromboembolism prevention in trauma patients: A Southwestern Surgical Congress Multicenter trial.
- Authors: Regner JL, Shaver CN, SWSC Multicenter Trials Group
- Issue date: 2019 Jun
- The survival benefit of low molecular weight heparin over unfractionated heparin in pediatric trauma patients.
- Authors: Khurrum M, Asmar S, Henry M, Ditillo M, Chehab M, Tang A, Bible L, Gries L, Joseph B
- Issue date: 2021 Mar
- A tale of two centers: Is low-molecular-weight heparin really superior for prevention of posttraumatic venous thromboembolism?
- Authors: Checchi KD, Costantini TW, Badiee J, Berndtson AE, Calvo RY, Rooney AS, Wessels LE, Prieto JM, Sise CB, Sise MJ, Martin MJ, Bansal V
- Issue date: 2021 Sep 1
- Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer.
- Authors: Van Matre ET, Reynolds PM, MacLaren R, Mueller SW, Wright GC, Moss M, Burnham EL, Ho PM, Vandivier RW, Kiser TH
- Issue date: 2018 Dec