The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor
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Endog_Opioid_Manuscript_Combin ...
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Final Accepted Manuscript
Affiliation
Univ Arizona, Coll Med, Dept PharmacolIssue Date
2020-04Keywords
35S-GTPγS couplingBiased agonism
Endogenous opioid peptides
Endomorphin
Forskolin-stimulated cAMP accumulation
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SPRINGER HEIDELBERGCitation
LaVigne, J., Keresztes, A., Chiem, D. et al. The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor. Pharmacol. Rep 72, 465–471 (2020). https://doi.org/10.1007/s43440-020-00061-xJournal
PHARMACOLOGICAL REPORTSRights
Copyright © 2020, Springer NatureCollection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Dynorphins, enkephalins, and endomorphins are endogenous opioid agonist peptides that may possess distinct bias profiles; biased agonism of endogenous peptides could explain the selective roles of these ligands in vivo. Our purpose in the present study was to investigate biased signaling and potential underlying molecular mechanisms of bias using 35S-GTPγS and cAMP assays, specifically focusing on the role of adenylyl cyclases (ACs) and regulators of G-protein signaling proteins (RGSs) in CHO, N2a, and SH-SY5Y cell lines, all expressing the human MOR.Note
12 month embargo; published online: 28 February 2020ISSN
1734-1140PubMed ID
32112361Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1007/s43440-020-00061-x