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    The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor

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    Author
    LaVigne, Justin
    Keresztes, Attila
    Chiem, Daniel
    Streicher, John M
    Affiliation
    Univ Arizona, Coll Med, Dept Pharmacol
    Issue Date
    2020-04
    Keywords
    35S-GTPγS coupling
    Biased agonism
    Endogenous opioid peptides
    Endomorphin
    Forskolin-stimulated cAMP accumulation
    
    Metadata
    Show full item record
    Publisher
    SPRINGER HEIDELBERG
    Citation
    LaVigne, J., Keresztes, A., Chiem, D. et al. The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor. Pharmacol. Rep 72, 465–471 (2020). https://doi.org/10.1007/s43440-020-00061-x
    Journal
    PHARMACOLOGICAL REPORTS
    Rights
    Copyright © 2020, Springer Nature
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Dynorphins, enkephalins, and endomorphins are endogenous opioid agonist peptides that may possess distinct bias profiles; biased agonism of endogenous peptides could explain the selective roles of these ligands in vivo. Our purpose in the present study was to investigate biased signaling and potential underlying molecular mechanisms of bias using 35S-GTPγS and cAMP assays, specifically focusing on the role of adenylyl cyclases (ACs) and regulators of G-protein signaling proteins (RGSs) in CHO, N2a, and SH-SY5Y cell lines, all expressing the human MOR.
    Note
    12 month embargo; published online: 28 February 2020
    ISSN
    1734-1140
    PubMed ID
    32112361
    DOI
    10.1007/s43440-020-00061-x
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1007/s43440-020-00061-x
    Scopus Count
    Collections
    UA Faculty Publications

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