• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Estimating the Relationships Between Early-Life Air Pollution Exposures and Wheezing From Birth Into Adulthood

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_17844_sip1_m.pdf
    Size:
    3.907Mb
    Format:
    PDF
    Download
    Author
    Lothrop, Nathan cc
    Issue Date
    2020
    Keywords
    air pollution
    childrens health
    exposure science
    Advisor
    Beamer, Paloma I.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Embargo
    Release after 05/15/2022
    Abstract
    Half of children in the United States experience wheezing incidents before their 6th birthday, and while most outgrow this condition, those who do not are at increased risk for irreversible decrements in lung function and development of asthma. During early life, lungs are more susceptible to environmental insults, however, findings on the association between ambient air pollution exposures in this time and wheezing outcomes are mixed, and effects on later wheezing outcomes have only been studied to age 11. To better understand these relationships, I took advantage of respiratory health data from the Tucson Children’s Respiratory Study (TCRS), one of the oldest on-going, prospective respiratory birth cohorts in the world, with 32 years of follow-up data (enrolled from 1980-1984, n=1246). I also utilized air pollution measures from two independent, spatially-representative air pollution studies in the Tucson, AZ area, the Pima County Workers Study (1987-1991) and the Tucson Air Pollution Study (2015-2016), to build and validate land use regression (LUR) models for NO2, NOx, PM2.5, and PM10, and then estimate exposures for TCRS participants at birth and age 6. Air pollution measurements from the Pima County Workers and Tucson Air Pollution Studies were well below ambient air quality standards, and concentrations decreased between the study periods, owing to regulations and controls enacted during this time. More sampling sites better characterized the relationships among predictors and pollutant concentrations, as shown by external validation, while the opposite was shown by internal validation. Decreased external validation capacity of LUR models can attenuate the effect of estimated air pollution exposures in health models. Despite relatively low concentrations of pollutants, PM2.5 exposures at birth significantly increased the risk of having wheezing in the first 3 years of life, which has been associated with reduced lung function and later development of asthma. Children born to mothers <25 years of age were more susceptible to NO2 and NOx exposures at birth for wheezing by age 3. NO2 exposures at birth also increased the risk of more frequent wheezing from age 8-32 years. Further reducing ambient concentrations of these pollutants through regulations or emissions controls could reduce the risk of these outcomes and future, long-term respiratory health implications.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Environmental Health Sciences
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.