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    Simplified method to quantify valve back-leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37

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    Name:
    Castorena_J_Physiology_2020.pdf
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    2.666Mb
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    Description:
    Final Accepted Manuscript
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    Author
    Castorena-Gonzalez, Jorge A
    Srinivasan, R Sathish
    King, Philip D
    Simon, Alexander M
    Davis, Michael J
    Affiliation
    Univ Arizona, Dept Physiol
    Issue Date
    2020-04-08
    Keywords
    Foxc2
    Rasa1
    back-leak
    connexin37
    connexin43
    lymph transport
    lymphatic vessel
    servo-null micropressure system
    valve function
    
    Metadata
    Show full item record
    Publisher
    WILEY
    Citation
    Castorena‐Gonzalez, J.A., Srinivasan, R.S., King, P.D., Simon, A.M. and Davis, M.J. (2020), Simplified method to quantify valve back‐leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37. J Physiol. doi:10.1113/JP279472
    Journal
    JOURNAL OF PHYSIOLOGY-LONDON
    Rights
    © 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Lymphatic valve defects are one of the major causes of lymph transport dysfunction; however, there are no accessible methods for quantitatively assessing valve function. This report describes a novel technique for quantifying lymphatic valve back-leak. Postnatal endothelial-specific deletion of connexin 43 (Cx43) in connexin 37 null (Cx37-/- ) mice results in rapid regression of valve leaflets and severe valve dysfunction. This method can also be used for assessing the function of venous and lymphatic valves from various species, including humans.
    Note
    12 month embargo; published online: 8 April 2020
    ISSN
    0022-3751
    EISSN
    1469-7793
    PubMed ID
    32267537
    DOI
    10.1113/JP279472
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1113/JP279472
    Scopus Count
    Collections
    UA Faculty Publications

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