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dc.contributor.authorCastorena-Gonzalez, Jorge A
dc.contributor.authorSrinivasan, R Sathish
dc.contributor.authorKing, Philip D
dc.contributor.authorSimon, Alexander M
dc.contributor.authorDavis, Michael J
dc.date.accessioned2020-06-02T21:46:32Z
dc.date.available2020-06-02T21:46:32Z
dc.date.issued2020-04-08
dc.identifier.citationCastorena‐Gonzalez, J.A., Srinivasan, R.S., King, P.D., Simon, A.M. and Davis, M.J. (2020), Simplified method to quantify valve back‐leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37. J Physiol. doi:10.1113/JP279472en_US
dc.identifier.issn0022-3751
dc.identifier.pmid32267537
dc.identifier.doi10.1113/JP279472
dc.identifier.urihttp://hdl.handle.net/10150/641505
dc.description.abstractLymphatic valve defects are one of the major causes of lymph transport dysfunction; however, there are no accessible methods for quantitatively assessing valve function. This report describes a novel technique for quantifying lymphatic valve back-leak. Postnatal endothelial-specific deletion of connexin 43 (Cx43) in connexin 37 null (Cx37-/- ) mice results in rapid regression of valve leaflets and severe valve dysfunction. This method can also be used for assessing the function of venous and lymphatic valves from various species, including humans.en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.rights© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectFoxc2en_US
dc.subjectRasa1en_US
dc.subjectback-leaken_US
dc.subjectconnexin37en_US
dc.subjectconnexin43en_US
dc.subjectlymph transporten_US
dc.subjectlymphatic vesselen_US
dc.subjectservo-null micropressure systemen_US
dc.subjectvalve functionen_US
dc.titleSimplified method to quantify valve back-leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37en_US
dc.typeArticleen_US
dc.identifier.eissn1469-7793
dc.contributor.departmentUniv Arizona, Dept Physiolen_US
dc.identifier.journalJOURNAL OF PHYSIOLOGY-LONDONen_US
dc.description.note12 month embargo; published online: 8 April 2020en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleThe Journal of physiology
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland


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