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    A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury

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    Pilot_Study_Waits.pdf
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    Final Accepted Manuscript
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    Author
    Waits, Charlotte Mae K
    Bower, Aaron
    Simms, Kelli N
    Feldman, Bradford C
    Kim, Nathan
    Sergeant, Susan
    Chilton, Floyd H
    VandeVord, Pamela J
    Langefeld, Carl D
    Rahbar, Elaheh
    Affiliation
    Univ Arizona, Dept Nutr Sci
    Univ Arizona, BIO5 Inst
    Issue Date
    2020-05-07
    Keywords
    FADS variation
    TBI
    inflammatory cytokines
    Omega-3 fatty acids
    rs174537
    
    Metadata
    Show full item record
    Publisher
    MARY ANN LIEBERT, INC
    Citation
    Waits, C. M. K., Bower, A., Simms, K. N., Feldman, B. C., Kim, N., Sergeant, S., ... & Rahbar, E. (2020). A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury. Journal of Neurotrauma.
    Journal
    JOURNAL OF NEUROTRAUMA
    Rights
    © Mary Ann Liebert, Inc.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Traumatic brain injury (TBI) is a leading cause of death and disability in persons under age 45. The hallmark secondary injury profile after TBI involves dynamic interactions between inflammatory and metabolic pathways including fatty acids. Omega-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) have been shown to provide neuroprotective benefits by minimizing neuroinflammation in rodents. These effects have been less conclusive in humans, however. We postulate genetic variants influencing PUFA metabolism in humans could contribute to these disparate findings. Therefore, we sought to (1) characterize the circulating PUFA response and (2) evaluate the impact of rs174537 on inflammation after TBI. A prospective, single-center, observational pilot study was conducted to collect blood samples from Level-1 trauma patients (N = 130) on admission and 24 h post-admission. Plasma was used to quantify PUFA levels and inflammatory cytokines. Deoxyribonucleic acid was extracted and genotyped at rs174537. Associations between PUFAs and inflammatory cytokines were analyzed for all trauma cases and stratified by race (Caucasians only), TBI (TBI: N = 47; non-TBI = 83) and rs174537 genotype (GG: N = 33, GT/TT: N = 44). Patients with TBI had higher plasma DHA levels compared with non-TBI at 24 h post-injury (p = 0.013). The SNP rs174537 was associated with both PUFA levels and inflammatory cytokines (p < 0.05). Specifically, TBI patients with GG genotype exhibited the highest plasma levels of DHA (1.33%) and interleukin-8 (121.5 ± 43.3 pg/mL), which were in turn associated with poorer outcomes. These data illustrate the impact of rs174537 on the post-TBI response. Further work is needed to ascertain how this genetic variant directly influences inflammation after trauma.
    Note
    12 month embargo; published online: 7 May 2020
    ISSN
    0897-7151
    EISSN
    1557-9042
    PubMed ID
    32253986
    DOI
    10.1089/neu.2019.6734
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1089/neu.2019.6734
    Scopus Count
    Collections
    UA Faculty Publications

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