Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans
Author
Sanguinetti, Joseph LHameroff, Stuart
Smith, Ezra E
Sato, Tomokazu
Daft, Chris M W
Tyler, William J
Allen, John J B
Affiliation
Univ Arizona, Dept PsycholUniv Arizona, Ctr Consciousness Studies
Univ Arizona, Dept Anesthesiol
Issue Date
2020-02-28
Metadata
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FRONTIERS MEDIA SACitation
Sanguinetti JL, Hameroff S, Smith EE, Sato T, Daft CMW, Tyler WJ and Allen JJB (2020) Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans. Front. Hum. Neurosci. 14:52. doi: 10.3389/fnhum.2020.00052Journal
FRONTIERS IN HUMAN NEUROSCIENCERights
Copyright © 2020 Sanguinetti, Hameroff, Smith, Sato, Daft, Tyler and Allen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Transcranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution and the ability to reach deep brain targets. Here we describe two experiments assessing whether tFUS could modulate mood in healthy human volunteers by targeting the right inferior frontal gyrus (rIFG), an area implicated in mood and emotional regulation. In a randomized, placebo-controlled, double-blind study, participants received 30 s of 500 kHz tFUS or a placebo control. Visual Analog Mood Scales (VAMS) assessed mood four times within an hour (baseline and three times after tFUS). Participants who received tFUS reported an overall increase in Global Affect (GA), an aggregate score from the VAMS scale, indicating a positive shift in mood. Experiment 2 examined resting-state functional (FC) connectivity using functional magnetic resonance imaging (fMRI) following 2 min of 500 kHz tFUS at the rIFG. As in Experiment 1, tFUS enhanced self-reported mood states and also decreased FC in resting state networks related to emotion and mood regulation. These results suggest that tFUS can be used to modulate mood and emotional regulation networks in the prefrontal cortex.Note
Open access journalISSN
1662-5161PubMed ID
32184714Version
Final published versionae974a485f413a2113503eed53cd6c53
10.3389/fnhum.2020.00052
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Except where otherwise noted, this item's license is described as Copyright © 2020 Sanguinetti, Hameroff, Smith, Sato, Daft, Tyler and Allen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
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