Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices
AuthorMelmed, Kara R
Schlick, Konrad H
Dumitrascu, Oana M
Padrick, Matthew M
Arabia, Francisco A
Moriguchi, Jaime D
Lyden, Patrick D
Song, Shlee S
AffiliationBanner Univ Arizona, Dept Surg & Med
KeywordsTranscranial Doppler ultrasound
high-intensity transient signal
Left ventricular assist device
MetadataShow full item record
CitationMelmed, K.R., Schlick, K.H., Rinsky, B., Dumitrascu, O.M., Volod, O., Nezhad, M., Padrick, M.M., Runyan, C., Arabia, F.A., Moriguchi, J.D., Lyden, P.D. and Song, S.S. (2020), Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices. Journal of Neuroimaging, 30: 297-302. doi:10.1111/jon.12694
JournalJOURNAL OF NEUROIMAGING
Rights© 2020 by the American Society of Neuroimaging.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBACKGROUND AND PURPOSE Mechanical circulatory support (MCS) devices are commonly used in heart failure patients. These devices carry risk for presumably embolic and additionally hemorrhagic stroke. Alterations in blood flow play a key role in stroke pathophysiology, and we aimed to learn more about hemodynamic compromise. In this study, we used transcranial Doppler (TCD) ultrasound to define hemodynamics of commonly used nonpulsatile MCS devices, as well as pulsatile devices, with special attention to the total artificial heart (TAH). METHODS From 2/2013 through 12/2016, we prospectively enrolled patients with MCS who underwent TCD imaging. We analyzed TCD parameters, including peak systolic velocity, end-diastolic velocity, pulsatility indices (PIs), and number of high-intensity transient signals. Waveform morphologies were compared between various MCS devices. RESULTS We performed 132 TCD studies in 86 MCS patients. Waveforms in patients supported by venoarterial-extracorporeal membrane oxygenation demonstrated continuous flow without clear systolic peaks with an average (+/- SD) PI of .43 (+/-.2). PIs were low in patients with continuous-flow left ventricular assist devices with a mean PI of .32 (+/-.13). Impella patients had morphologically distinct pulsatile waveforms and a higher mean PI of .65 (+/-.24). In intra-arterial balloon pump patients, mean PI was 1.01 (+/-.16) and diastolic upstrokes were pronounced. In TAH patients, mean middle cerebral artery velocity of 79.69 (+/- 32.33) cm/seconds and PI of .74 (+/-.14) approached normal values. CONCLUSION TCD can detect characteristic waveforms in patients supported by various MCS devices. These device-specific TCD patterns are recognizable and reproducible.
Note12 month embargo; published online: 10 February 2020
VersionFinal accepted manuscript
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