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    Treatment for Early, Uncomplicated Coccidioidomycosis: What Is Success?

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    accepted_cocci_assessment.pdf
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    Author
    Galgiani, John N
    Blair, Janis E
    Ampel, Neil M
    Thompson, George R
    Affiliation
    Univ Arizona, Coll Med, Valley Fever Ctr Excellence
    Univ Arizona, Coll Med, Dept Med
    Issue Date
    2019-09-23
    Keywords
    azole antifungals
    coccidioidomycosis
    Symptoms
    treatment
    
    Metadata
    Show full item record
    Publisher
    OXFORD UNIV PRESS INC
    Citation
    John N Galgiani, Janis E Blair, Neil M Ampel, George R Thompson, Treatment for Early, Uncomplicated Coccidioidomycosis: What Is Success?, Clinical Infectious Diseases, Volume 70, Issue 9, 1 May 2020, Pages 2008–2012, https://doi.org/10.1093/cid/ciz933
    Journal
    CLINICAL INFECTIOUS DISEASES
    Rights
    Copyright © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The care of primary pulmonary coccidioidomycosis remains challenging. Such infections produce a variety of signs, symptoms, and serologic responses that cause morbidity in patients and concern in treating clinicians for the possibility of extrapulmonary dissemination. Illness may be due to ongoing fungal growth that produces acute inflammatory responses, resulting in tissue damage and necrosis, and for this, administering an antifungal drug may be of benefit. In contrast, convalescence may be prolonged by other immunologic reactions to infection, even after fungal replication has been arrested, and in those situations, antifungal therapy is unlikely to yield clinical improvement. In this presentation, we discuss what findings are clinical indicators of fungal growth and what other sequelae are not. Understanding these differences provides a rational management strategy for deciding when to continue, discontinue, or reinstitute antifungal treatments.
    Note
    12 month embargo; published online: 23 September 2019
    ISSN
    1058-4838
    PubMed ID
    31544210
    DOI
    10.1093/cid/ciz933
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciz933
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

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