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    Early-life ketamine exposure attenuates the preference for ethanol in adolescent Sprague-Dawley rats

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    Author
    Franco, Daniela
    Zamudio, Jennifer
    Blevins, Kennedy M
    Núñez-Larios, Eric A
    Ricoy, Ulises M
    Iñiguez, Sergio D
    Zavala, Arturo R
    Affiliation
    Univ Arizona, Dept Neurosci
    Issue Date
    2020-07-01
    Keywords
    Addiction
    Adolescence
    alcohol
    anhedonia
    CPP
    Reward
    
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    ELSEVIER
    Citation
    Franco, D., Zamudio, J., Blevins, K. M., Núñez-Larios, E. A., Ricoy, U. M., Iñiguez, S. D., & Zavala, A. R. (2020). Early-life ketamine exposure attenuates the preference for ethanol in adolescent Sprague-Dawley rats. Behavioural Brain Research, 112626. https://doi.org/10.1016/j.bbr.2020.112626
    Journal
    BEHAVIOURAL BRAIN RESEARCH
    Rights
    Copyright © 2020 Elsevier B.V. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces quick and effective antidepressant results in depressed juvenile and adult individuals. The long-term consequences of using ketamine in juvenile populations are not well known, particularly as it affects vulnerability to drugs of abuse later in life, given that ketamine is also a drug of abuse. Thus, the current study examined whether early-life ketamine administration produces long-term changes in the sensitivity to the rewarding effects of ethanol, as measured using the conditioned place preference (CPP) paradigm. On postnatal day (PD) 21, juvenile male and female rats were pretreated with ketamine (0.0 or 20 mg/kg) for 10 consecutive days (i.e., PD 21-30) and then evaluated for ethanol-induced CPP (0.0, 0.125, 0.5, or 2.0 g/kg) from PD 32 - 39. Results revealed that early-life ketamine administration attenuated the rewarding properties of ethanol in male rats, as ketamine pretreated rats failed to exhibit ethanol-induced CPP at any dose compared to saline pretreated rats, which showed an increased preference towards the ethanol-paired compartment in a dose-dependent manner. In females, ethanol-induced CPP was generally less robust compared to males, but ketamine pretreatment resulted in a rightward shift in the dose-response curve, given that ketamine pretreated rats needed a higher dose of ethanol compared to saline pretreated rats to exhibit ethanol-induced CPP. When considered together, the findings suggest that early use of ketamine does not appear to enhance the vulnerability to ethanol later in life, but in contrast, it may attenuate the rewarding effects of ethanol.
    Note
    18 month embargo; published online: 30 April 2020
    ISSN
    0166-4328
    EISSN
    1872-7549
    PubMed ID
    32361040
    DOI
    10.1016/j.bbr.2020.112626
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbr.2020.112626
    Scopus Count
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