Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension
Author
Karnes, Jason HWiener, Howard W
Schwantes-An, Tae-Hwi
Natarajan, Balaji
Sweatt, Andrew J
Chaturvedi, Abhishek
Arora, Amit
Batai, Ken
Nair, Vineet
Steiner, Heidi E
Giles, Jason B
Yu, Jeffrey
Hosseini, Maryam
Pauciulo, Michael W
Lutz, Katie A
Coleman, Anna W
Feldman, Jeremy
Vanderpool, Rebecca
Tang, Haiyang
Garcia, Joe G N
Yuan, Jason X-J
Kittles, Rick
de Jesus Perez, Vinicio
Zamanian, Roham T
Rischard, Franz
Tiwari, Hemant K
Nichols, William C
Benza, Raymond L
Desai, Ankit A
Affiliation
Univ Arizona, Dept Epidemiol & BiostatUniv Arizona, Dept Med
Univ Arizona, Dept Surg
Univ Arizona, Dept Pharm Practice & Sci
Issue Date
2020-01-09
Metadata
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AMER THORACIC SOCCitation
Karnes, J. H., Wiener, H. W., Schwantes-An, T. H., Natarajan, B., Sweatt, A. J., Chaturvedi, A., ... & Giles, J. B. (2020). Genetic admixture and survival in diverse populations with pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 201(11), 1407-1415.Rights
Copyright © 2020 by the American Thoracic Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH). Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH. Methods: Patients with Group 1 PAH were included from two national registries with genome-wide data and two local cohorts, and further incorporated in a global meta-analysis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for transplant-free, all-cause mortality in Hispanic patients with non-Hispanic white (NHW) patients as the reference group. Odds ratios (ORs) for inpatient-specific mortality in patients with PAH were also calculated for race/ethnic groups from an additional National Inpatient Sample dataset not included in the meta-analysis. Measurements and Main Results: After covariate adjustment, self-reported Hispanic patients (n = 290) exhibited significantly reduced mortality versus NHW patients (n = 1,970) after global meta-analysis (HR, 0.60 [95% CI, 0.41-0.87]; P = 0.008). Although not significant, increasing Native American genetic ancestry appeared to account for part of the observed mortality benefit (HR, 0.48 [95% CI, 0.23-1.01]; P= 0.053) in the two national registries. Finally, in the National Inpatient Sample, an inpatient mortality benefit was also observed for Hispanic patients (n = 1,524) versus NHW patients (n = 8,829; OR, 0.65 [95% CI, 0.50-0.84]; P = 0.001). An inpatient mortality benefit was observed for Native American patients (n = 185; OR, 0.38 [95% CI, 0.15-0.93]; P= 0.034). Conclusions: This study demonstrates a reproducible survival benefit for Hispanic patients with Group 1 PAH in multiple clinical settings. Our results implicate contributions of genetic ancestry to differential survival in PAH.Note
12 month embargo; published online: 9 January 2020ISSN
1073-449XPubMed ID
31916850Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1164/rccm.201907-1447OC
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