Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension
AuthorKarnes, Jason H
Wiener, Howard W
Sweatt, Andrew J
Steiner, Heidi E
Giles, Jason B
Pauciulo, Michael W
Lutz, Katie A
Coleman, Anna W
Garcia, Joe G N
Yuan, Jason X-J
de Jesus Perez, Vinicio
Zamanian, Roham T
Tiwari, Hemant K
Nichols, William C
Benza, Raymond L
Desai, Ankit A
AffiliationUniv Arizona, Dept Epidemiol & Biostat
Univ Arizona, Dept Med
Univ Arizona, Dept Surg
Univ Arizona, Dept Pharm Practice & Sci
MetadataShow full item record
PublisherAMER THORACIC SOC
CitationKarnes, J. H., Wiener, H. W., Schwantes-An, T. H., Natarajan, B., Sweatt, A. J., Chaturvedi, A., ... & Giles, J. B. (2020). Genetic admixture and survival in diverse populations with pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 201(11), 1407-1415.
RightsCopyright © 2020 by the American Thoracic Society
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractRationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH). Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH. Methods: Patients with Group 1 PAH were included from two national registries with genome-wide data and two local cohorts, and further incorporated in a global meta-analysis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for transplant-free, all-cause mortality in Hispanic patients with non-Hispanic white (NHW) patients as the reference group. Odds ratios (ORs) for inpatient-specific mortality in patients with PAH were also calculated for race/ethnic groups from an additional National Inpatient Sample dataset not included in the meta-analysis. Measurements and Main Results: After covariate adjustment, self-reported Hispanic patients (n = 290) exhibited significantly reduced mortality versus NHW patients (n = 1,970) after global meta-analysis (HR, 0.60 [95% CI, 0.41-0.87]; P = 0.008). Although not significant, increasing Native American genetic ancestry appeared to account for part of the observed mortality benefit (HR, 0.48 [95% CI, 0.23-1.01]; P= 0.053) in the two national registries. Finally, in the National Inpatient Sample, an inpatient mortality benefit was also observed for Hispanic patients (n = 1,524) versus NHW patients (n = 8,829; OR, 0.65 [95% CI, 0.50-0.84]; P = 0.001). An inpatient mortality benefit was observed for Native American patients (n = 185; OR, 0.38 [95% CI, 0.15-0.93]; P= 0.034). Conclusions: This study demonstrates a reproducible survival benefit for Hispanic patients with Group 1 PAH in multiple clinical settings. Our results implicate contributions of genetic ancestry to differential survival in PAH.
Note12 month embargo; published online: 9 January 2020
VersionFinal accepted manuscript
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