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    Human Cytomegalovirus Infection Suppresses CD34(+) Progenitor Cell Engraftment in Humanized Mice

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    microorganisms-08-00525.pdf
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    Author
    Crawford, Lindsey B
    Tempel, Rebecca
    Streblow, Daniel N
    Yurochko, Andrew D
    Goodrum, Felicia D
    Nelson, Jay A
    Caposio, Patrizia
    Affiliation
    Univ Arizona, BIO5 Inst, Dept Immunobiol
    Issue Date
    2020-04-06
    Keywords
    Hematopoiesis
    hematopoietic stem cell transplant
    Human Cytomegalovirus
    humanized mice
    myelosuppression
    progenitor cell
    
    Metadata
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    Publisher
    MDPI
    Citation
    Crawford, L.B.; Tempel, R.; Streblow, D.N.; Yurochko, A.D.; Goodrum, F.D.; Nelson, J.A.; Caposio, P. Human Cytomegalovirus Infection Suppresses CD34+ Progenitor Cell Engraftment in Humanized Mice. Microorganisms 2020, 8, 525.
    Journal
    MICROORGANISMS
    Rights
    Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Human cytomegalovirus (HCMV) infection is a serious complication in hematopoietic stem cell transplant (HSCT) recipients due to virus-induced myelosuppression and impairment of stem cell engraftment. Despite the clear clinical link between myelosuppression and HCMV infection, little is known about the mechanism(s) by which the virus inhibits normal hematopoiesis because of the strict species specificity and the lack of surrogate animal models. In this study, we developed a novel humanized mouse model system that recapitulates the HCMV-mediated engraftment failure after hematopoietic cell transplantation. We observed significant alterations in the hematopoietic populations in peripheral lymphoid tissues following engraftment of a subset of HCMV+ CD34(+) hematopoietic progenitor cells (HPCs) within the transplant, suggesting that a small proportion of HCMV-infected CD34(+) HPCs can profoundly affect HPC differentiation in the bone marrow microenvironment. This model will be instrumental to gain insight into the fundamental mechanisms of HCMV myelosuppression after HSCT and provides a platform to assess novel treatment strategies.
    Note
    Open access journal
    ISSN
    2076-2607
    PubMed ID
    32268565
    DOI
    10.3390/microorganisms8040525
    Version
    Final published version
    ae974a485f413a2113503eed53cd6c53
    10.3390/microorganisms8040525
    Scopus Count
    Collections
    UA Faculty Publications

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