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dc.contributor.authorVedantham, Srinivasan
dc.contributor.authorTseng, Hsin-Wu
dc.contributor.authorKonate, Souleymane
dc.contributor.authorShi, Linxi
dc.contributor.authorKarellas, Andrew
dc.date.accessioned2020-07-14T23:00:14Z
dc.date.available2020-07-14T23:00:14Z
dc.date.issued2020
dc.identifier.citationVedantham, S., Tseng, H. W., Konate, S., Shi, L., & Karellas, A. (2020). Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation. Journal of X-ray science and technology, 28(3), 405–426.en_US
dc.identifier.issn0895-3996
dc.identifier.pmid32333575
dc.identifier.doi10.3233/XST-200651
dc.identifier.urihttp://hdl.handle.net/10150/641858
dc.description.abstractBACKGROUND: High-resolution, low-noise detectors with minimal dead-space at chest-wall could improve posterior coverage and microcalcification visibility in the dedicated cone-beam breast CT (CBBCT). However, the smaller field-of-view necessitates laterally-shifted detector geometry to enable optimizing the air-gap for x-ray scatter rejection. OBJECTIVE: To evaluate laterally-shifted detector geometry for CBBCT with clinical projection datasets that provide for anatomical structures and lesions. METHODS: CBBCT projection datasets (n = 17 breasts) acquired with a 40×30 cm detector (1024×768-pixels, 0.388-mm pixels) were truncated along the fan-angle to emulate 20.3×30 cm, 22.2×30 cm and 24.1×30 cm detector formats and correspond to 20, 120, 220 pixels overlap in conjugate views, respectively. Feldkamp-Davis-Kress (FDK) algorithm with 3 different weighting schemes were used for reconstruction. Visual analysis for artifacts and quantitative analysis of root-mean-squared-error (RMSE), absolute difference between truncated and 40×30 cm reconstructions (Diff), and its power spectrum (PSDiff) were performed. RESULTS:Artifacts were observed for 20.3×30 cm, but not for other formats. The 24.1×30 cm provided the best quantitative results with RMSE and Diff (both in units of μ, cm-1) of 4.39×10-3±1.98×10-3 and 4.95×10-4±1.34×10-4, respectively. The PSDiff (>0.3 cycles/mm) was in the order of 10-14μ2mm3 and was spatial-frequency independent. CONCLUSIONS: Laterally-shifted detector CBBCT with at least 220 pixels overlap in conjugate views (24.1×30 cm detector format) provides quantitatively accurate and artifact-free image reconstruction.en_US
dc.language.isoenen_US
dc.publisherIOS PRESSen_US
dc.rightsCopyright ©2020 IOS Press. All rights reserved.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectbreasten_US
dc.subjectX-Ray computed tomography (CT)en_US
dc.subjectbreast CTen_US
dc.subjectcone-beam CTen_US
dc.subjectMammographyen_US
dc.titleDedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translationen_US
dc.typeArticleen_US
dc.identifier.eissn1095-9114
dc.contributor.departmentUniv Arizona, Med Imaging & Biomed Engnen_US
dc.identifier.journalJOURNAL OF X-RAY SCIENCE AND TECHNOLOGYen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleJournal of X-ray science and technology
dc.source.volume28
dc.source.issue3
dc.source.beginpage405
dc.source.endpage426
refterms.dateFOA2020-07-14T23:00:18Z
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryNetherlands


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