Serum Potassium Levels at Hospital Discharge and One-Year Mortality among Hospitalized Patients
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Thongprayoon, CharatCheungpasitporn, Wisit
Thirunavukkarasu, Sorkko
Petnak, Tananchai
Chewcharat, Api
Bathini, Tarun
Vallabhajosyula, Saraschandra
Mao, Michael A
Erickson, Stephen B
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Univ Arizona, Dept Internal MedIssue Date
2020-05-14
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Thongprayoon, C.; Cheungpasitporn, W.; Thirunavukkarasu, S.; Petnak, T.; Chewcharat, A.; Bathini, T.; Vallabhajosyula, S.; Mao, M.A.; Erickson, S.B. Serum Potassium Levels at Hospital Discharge and One-Year Mortality among Hospitalized Patients. Medicina 2020, 56, 236.Journal
MEDICINA-LITHUANIARights
Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background and Objectives: The optimal range of serum potassium at hospital discharge is unclear. The aim of this study was to assess the relationship between discharge serum potassium levels and one-year mortality in hospitalized patients. Materials and Methods: All adult hospital survivors between 2011 and 2013 at a tertiary referral hospital, who had available admission and discharge serum potassium data, were enrolled. End-stage kidney disease patients were excluded. Discharge serum potassium was defined as the last serum potassium level measured within 48 h prior to hospital discharge and categorized into <= 2.9, 3.0-3.4, 3.5-3.9, 4.0-4.4, 4.5-4.9, 5.0-5.4 and >= 5.5 mEq/L. A Cox proportional hazards analysis was performed to assess the independent association between discharge serum potassium and one-year mortality after hospital discharge, using the discharge potassium range of 4.0-4.4 mEq/L as the reference group. Results: Of 57,874 eligible patients, with a mean discharge serum potassium of 4.1 +/- 0.4 mEq/L, the estimated one-year mortality rate after discharge was 13.2%. A U-shaped association was observed between discharge serum potassium and one-year mortality, with the nadir mortality in the discharge serum potassium range of 4.0-4.4 mEq/L. After adjusting for clinical characteristics, including admission serum potassium, both discharge serum potassium <= 3.9 mEq/L and >= 4.5 mEq/L were significantly associated with increased one-year mortality, compared with the discharge serum potassium of 4.0-4.4 mEq/L. Stratified analysis based on admission serum potassium showed similar results, except that there was no increased risk of one-year mortality when discharge serum potassium was <= 3.9 mEq/L in patients with an admission serum potassium of >= 5.0 mEq/L. Conclusion: The association between discharge serum potassium and one-year mortality after hospital discharge had a U-shaped distribution and was independent of admission serum potassium. Favorable survival outcomes occurred when discharge serum potassium was strictly within the range of 4.0-4.4 mEq/L.Note
Open access journalISSN
1010-660XPubMed ID
32423140Version
Final published versionae974a485f413a2113503eed53cd6c53
10.3390/medicina56050236
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Except where otherwise noted, this item's license is described as Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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