Extent and Factors Associated with Adherence to Antidepressant Treatment During Acute and Continuation Phase Depression Treatment Among Older Adults with Dementia and Major Depressive Disorder
Lee, Jeannie K
Patanwala, Asad E
Malone, Daniel C
Knapp, Shannon M
Burke, William J
AffiliationUniv Arizona, Coll Pharm, Dept Pharm Practice & Sci
Univ Arizona, Stat Consulting Lab, Bio5 Inst
acute phase depression
continuation phase depression
MetadataShow full item record
PublisherDOVE MEDICAL PRESS LTD
CitationBhattacharjee, S., Lee, J., Vadiei, N., Patanwala, A., Malone, D., & Knapp, S. et al. (2020). Extent and Factors Associated with Adherence to Antidepressant Treatment During Acute and Continuation Phase Depression Treatment Among Older Adults with Dementia and Major Depressive Disorder. Neuropsychiatric Disease And Treatment, Volume 16, 1433-1450. doi: 10.2147/ndt.s241749
RightsCopyright © 2020 Bhattacharjee et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/).
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AbstractPurpose: Little is known about adherence to antidepressant treatment during acute and continuation phase of depression among older adults with dementia and newly diagnosed major depressive disorders (MDD). This study estimated the extent of and factors associated with adherence to acute and continuation phase antidepressant treatment among older adults with dementia and newly diagnosed MDD. Methods: We conducted a retrospective cohort study using the Medicare 5% sample claims data (2012-2013) among older adults (age >= 65 years) with dementia who were newly diagnosed with MDD. Intake period of our study was from 01-May-2012 through 30April-2013. The dependent variables of this study were acute and continuation phase depression treatment adherence. Factors associated with acute and continuation phase antidepressant treatment adherence were identified using multiple logistic regression analyses. Results: The final study sample consisted of 6239 [adherent: N=4644 (74.44%)] and 5617 [adherent: N=3584 (63.81%)] older adults with dementia and MDD during the acute and continuation phase treatment, respectively. During the acute phase, only race/ethnicity was significantly associated with adherence to depression treatment, whereas race/ethnicity and baseline antipsychotic use were significantly associated with adherence to depression treatment during the continuation phase. Conclusion: Approximately, 74% and 64% older adults with dementia and MDD were adherent to acute and continuation phase antidepressant treatment in this nationally representative sample of Medicare beneficiaries, and we identified several modifiable and nonmodifiable factors associated with adherence.
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Except where otherwise noted, this item's license is described as Copyright © 2020 Bhattacharjee et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/).
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The reactions of depressives to depressives: The interpersonal consequences of depression.Greenberg, Jeff; Rosenblatt, Abram B.; Arkowitz, Harold S.; Pool, Ron (The University of Arizona., 1988)Two studies were conducted to examine the interpersonal world of the depressive. It was hypothesized that depressed subjects would not like nondepressed targets as much as would nondepressed subjects. In addition, it was hypothesized that depressed subjects would feel worse after speaking with nondepressed targets. Finally it was hypothesized that perceived similarity would mediate these effects by covarying with mood and liking measures. To assess these hypotheses, study one had depressed and nondepressed college students speak with one another in either depressed-depressed, nondepressed-depressed, or nondepressed-nondepressed pairs. Measures of liking for the person with whom they conversed, of perceived similarity toward the person with whom they conversed, and of the subject's mood were then taken. Although the results were mixed, it was found that depressed subjects felt worse after speaking to depressed targets, though there were no differences in liking or perceived similarity between the groups. Perceived similarity did covary with most of the liking measures for the depressed and nondepressed subjects. Study two examined whether depressives had best friends who were themselves more depressed than best friends who were nondepressives. It was hypothesized that the best friends of depressives would be more depressed. Furthermore, it was expected that the best friends would also be perceived as more depressed by the subjects. These hypotheses were confirmed when depressives brought their best friends in for a study and the level of depression for these best friends was measured. In addition, the depressed subjects reported feeling worse after speaking with their friends when compared to how the nondepressed subjects reported feeling after speaking with their best friends.
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Patterns and predictors of depression treatment among adults with chronic kidney disease and depression in ambulatory care settings in the United StatesVadiei, Nina; Bhattacharjee, Sandipan; Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci (SPRINGER, 2019-02-01)One in five adults with chronic kidney disease (CKD) in the United States (US) suffers from depression. Comorbid depression in adults with CKD is associated with higher morbidity and mortality. This study used US national survey data to examine patterns and predictors of depression treatment among adults with non-dialysis-dependent CKD in the US. A retrospective, cross-sectional study was conducted using 2014-2015 National Ambulatory Medical Care Survey (NAMCS) data. The final study sample consisted of visits by 9.02 million adults (unweighted n = 262; age ≥ 18 years) with CKD and depression in the US. Depression treatment was defined as antidepressant use with or without psychotherapy. To identify predictors of depression treatment, multivariable logistic regression analysis was conducted adjusting for predisposing, enabling, and need factors. Approximately half of adults with CKD and depression received depression treatment. Primary care was the main setting of treatment, and the most commonly prescribed antidepressant class was selective serotonin reuptake inhibitors. Adults being seen for treatment of a chronic problem were 3.2 times more likely to receive depression treatment (OR 3.20; 95% CI 1.38-7.21). In addition, there was a 9% higher likelihood of receiving depression treatment for each unit increase in total number of medications (OR 1.09; 95% CI 1.01-1.19). Finally, adults receiving care in the South were 63% less likely to receive depression treatment (OR 0.37; 95% CI 0.15-0.89). Depression treatment was recorded in approximately half of US ambulatory care visits involving adults with CKD and depression from 2014 to 2015. Further research is warranted to determine how to appropriately manage treatment of depression in adults with CKD.