Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT
AffiliationUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat
MetadataShow full item record
PublisherAMER DIABETES ASSOC
CitationNuyujukian, D. S., Koska, J., Bahn, G., Reaven, P. D., Zhou, J. J., & VADT Investigators. (2020). Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT. Diabetes Care. https://doi.org/10.2337/dc19-2540
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AbstractIn ACCORD, CV and ARV of SBP and DBP were associated with increased risk of HF, even after adjusting for other risk factors and mean blood pressure (e.g., CV-SBP: hazard ratio [HR] 1.15, P = 0.01; CV-DBP: HR 1.18, P = 0.003). In the VADT, DBP variability was associated with increased risk of HF (ARV-DBP: HR 1.16, P = 0.001; CV-DBP: HR 1.09, P = 0.04). Further, in ACCORD, those with progressively lower baseline blood pressure demonstrated a stepwise increase in risk of HF with higher CV-SBP, ARV-SBP, and CV-DBP. Effects of blood pressure variability were related to dips, not elevations, in blood pressure.
VersionFinal accepted manuscript
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