Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT

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Author
Nuyujukian, Daniel S
Koska, Juraj
Bahn, Gideon
Reaven, Peter D
Zhou, Jin J
Affiliation
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat
Issue Date
2020-07

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Publisher
AMER DIABETES ASSOC
Citation
Nuyujukian, D. S., Koska, J., Bahn, G., Reaven, P. D., Zhou, J. J., & VADT Investigators. (2020). Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT. Diabetes Care. https://doi.org/10.2337/dc19-2540
Journal
DIABETES CARE
Rights
© 2020 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.
Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract
In ACCORD, CV and ARV of SBP and DBP were associated with increased risk of HF, even after adjusting for other risk factors and mean blood pressure (e.g., CV-SBP: hazard ratio [HR] 1.15, P = 0.01; CV-DBP: HR 1.18, P = 0.003). In the VADT, DBP variability was associated with increased risk of HF (ARV-DBP: HR 1.16, P = 0.001; CV-DBP: HR 1.09, P = 0.04). Further, in ACCORD, those with progressively lower baseline blood pressure demonstrated a stepwise increase in risk of HF with higher CV-SBP, ARV-SBP, and CV-DBP. Effects of blood pressure variability were related to dips, not elevations, in blood pressure.
ISSN
0149-5992
EISSN
1935-5548
PubMed ID
32327422
DOI
10.2337/dc19-2540
Version
Final accepted manuscript
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