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    Immunoglobulin A vasculitis associated with inflammatory bowel disease: a retrospective cohort study

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    Villatoro-Villar_et_al,_IgA_va ...
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    Author
    Villatoro-Villar, M
    Crowson, C S
    Warrington, K J
    Makol, A
    Koster, M J
    Affiliation
    Univ Arizona, Div Rheumatol, Arthrit Ctr
    Issue Date
    2020-05-27
    
    Metadata
    Show full item record
    Publisher
    TAYLOR & FRANCIS LTD
    Citation
    M Villatoro-Villar, CS Crowson, KJ Warrington, A Makol & MJ Koster (2020) Immunoglobulin A vasculitis associated with inflammatory bowel disease: a retrospective cohort study, Scandinavian Journal of Rheumatology, DOI: 10.1080/03009742.2020.1732460
    Journal
    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
    Rights
    Copyright © 2020 Informa UK Limited.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Objective To describe the baseline characteristics and outcome of a series of patients with inflammatory bowel disease (IBD) and immunoglobulin A vasculitis (IgAV). Method Patients with biopsy-proven IgAV with IBD were identified retrospectively. Data were abstracted from direct medical chart review. Each IBD-IgAV case was matched to two controls with IgAV but without IBD. Results Nine patients were identified (seven Crohn's disease, two ulcerative colitis). Mean length of time between IBD diagnosis and IgAV onset was 17.3 +/- 19.9 years. For patients on biologic treatment for IBD, mean length of time between biologic initiation and IgAV onset was 3.3 +/- 3.8 years. Active IBD at IgAV onset was present in 56%. Tumour necrosis factor inhibitors (TNFi) were used for IBD in 89%. At IgAV onset, six patients were on treatment with TNFi; one subsequently discontinued, two switched to another TNFi, and three continued. At the last follow-up, three of five patients who remained on TNFi had full resolution of IgAV despite ongoing TNFi use. No differences were seen between cases with IBD IgAV and matched non-IBD-IgAV controls regarding development of end-stage renal disease, resolution of haematuria or proteinuria, and time to complete IgAV response. Conclusion Baseline characteristics and outcomes of patients with IBD-IgAV are similar to those with IgAV without IBD. Development of IgAV is not limited to patients with clinically active IBD. Whether TNFi use is related to the pathogenesis of IgAV in some patients with IBD remains unclear. Further research into pathophysiological connections between IBD and IgAV is needed.
    Note
    12 month embargo; published online: 27 May 2020
    ISSN
    0300-9742
    EISSN
    1502-7732
    PubMed ID
    32456601
    DOI
    10.1080/03009742.2020.1732460
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1080/03009742.2020.1732460
    Scopus Count
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    UA Faculty Publications

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