• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Heat_shock_protein_90_inhibito ...
    Size:
    1006.Kb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
    Download
    Author
    Stine, Carrie
    Coleman, Deziree L.
    Flohrschutz, Austin T.
    Thompson, Austen L.
    Mishra, Sanket
    Blagg, Brian S.
    Largent-Milnes, Tally M.
    Lei, Wei
    Streicher, John M.
    Affiliation
    Univ Arizona, Coll Med, Dept Pharmacol
    Issue Date
    2020-04-10
    Keywords
    Heat shock protein 90
    Opioids
    Cancer
    Pain
    Chemotherapy-induced peripheral neuropathy
    Cancer-induced bone pain
    
    Metadata
    Show full item record
    Publisher
    LIPPINCOTT WILLIAMS & WILKINS
    Citation
    Stine, Carriea; Coleman, Deziree L.a; Flohrschutz, Austin T.a; Thompson, Austen L.a; Mishra, Sanketb; Blagg, Brian S.b; Largent-Milnes, Tally M.a; Lei, Weia,c; Streicher, John M.a,* Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models, PAIN: August 2020 - Volume 161 - Issue 8 - p 1798-1807 doi: 10.1097/j.pain.0000000000001886
    Journal
    PAIN
    Rights
    Copyright © 2020 International Association for the Study of Pain.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 inhibitors injected into the brain block opioid-induced antinociception in tail flick, paw incision, and HIV neuropathy pain. This study extended from that initial work to test the cancer-related clinical impact of Hsp90 inhibitors on opioid antinociception in cancer-induced bone pain in female BALB/c mice and chemotherapy-induced peripheral neuropathy in male and female CD-1 mice. Mice were treated with Hsp90 inhibitors (17-AAG, KU-32) by the intracerebroventricular, intrathecal, or intraperitoneal routes, and after 24 hours, pain behaviors were evaluated after analgesic drug treatment. Heat shock protein 90 inhibition in the brain or systemically completely blocked morphine and oxymorphone antinociception in chemotherapy-induced peripheral neuropathy; this effect was partly mediated by decreased ERK and JNK MAPK activation and by increased protein translation, was not altered by chronic treatment, and Hsp90 inhibition had no effect on gabapentin antinociception. We also found that the Hsp90 isoform Hsp90 alpha and the cochaperone Cdc37 were responsible for the observed changes in opioid antinociception. By contrast, Hsp90 inhibition in the spinal cord or systemically partially reduced opioid antinociception in cancer-induced bone pain. These results demonstrate that Hsp90 inhibitors block opioid antinociception in cancer-related pain, suggesting that Hsp90 inhibitors for cancer therapy could decrease opioid treatment efficacy.
    Note
    12 month embargo; published 01 August 2020
    ISSN
    0304-3959
    PubMed ID
    32701840
    DOI
    10.1097/j.pain.0000000000001886
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1097/j.pain.0000000000001886
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.
    • Authors: Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, Edwards K, Bilsky EJ, Streicher JM
    • Issue date: 2017 Jun 23
    • Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment.
    • Authors: Duron DI, Tanguturi P, Campbell CS, Chou K, Bejarano P, Gabriel KA, Bowden JL, Mishra S, Brackett C, Barlow D, Houseknecht KL, Blagg BSJ, Streicher JM
    • Issue date: 2024 Jun 26
    • The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain.
    • Authors: Lei W, Duron DI, Stine C, Mishra S, Blagg BSJ, Streicher JM
    • Issue date: 2019
    • Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.
    • Authors: Guindon J, Lai Y, Takacs SM, Bradshaw HB, Hohmann AG
    • Issue date: 2013 Jan
    • Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway.
    • Authors: Duron DI, Lei W, Barker NK, Stine C, Mishra S, Blagg BSJ, Langlais PR, Streicher JM
    • Issue date: 2020 May 5
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.