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dc.contributor.authorMajak, W.
dc.contributor.authorStroesser, L.
dc.contributor.authorLysyk, T.
dc.contributor.authorHall, J. W.
dc.date.accessioned2020-09-18T04:00:51Z
dc.date.available2020-09-18T04:00:51Z
dc.date.issued2003-05-01
dc.identifier.citationMajak, W., Stroesser, L., Lysyk, T., & Hall, J. W. (2003). Toxicity and development of tolerance in cattle to timber milkvetch. Journal of Range Management, 56(3), 266-272.
dc.identifier.issn0022-409X
dc.identifier.doi10.2307/4003817
dc.identifier.doi10.2458/azu_jrm_v56i3_majak
dc.identifier.urihttp://hdl.handle.net/10150/643437
dc.description.abstractTimber milkvetch (TMV, Astragalus miser Dougl. ex Hook var. serotinus) is widely distributed on rangelands in the southern interior of British Columbia, Canada. It synthesizes large quantities of miserotoxin, a glycoside that is toxic to cattle. Six grazing studies were conducted at Sixtyone Creek on the Cariboo Plateau during 1993 to 2000 to determine which class of livestock was most susceptible to TMV, to record clinical signs of poisoning under range conditions, and to determine the efficacy of protein supplements for the prevention of TMV poisoning. In vitro rates of TMV detoxification in rumen fluid were determined concurrently. Incidents of early, acute and chronic poisoning were documented using a total of 143 cows over the 6 year study. Older cows (more than 3-years old) and yearling heifers were less susceptible to TMV than lactating first-calf heifers, which showed acute signs of poisoning. A chronic syndrome was sometimes seen in second-calf heifers, especially during exertion. Heifers not previously exposed to TMV, such as those that were obtained from the prairie region of Alberta, were also more susceptible than cattle originating in B.C. with a known history of exposure to TMV. Each year, Hereford cows were divided into 2 groups, one of which received free-choice protein supplements in a molasses block, the other did not receive supplement and served as a control group during the 6-week grazing trial. The control group yielded 25 cases of TMV poisoning during the 6-year study, compared with 2 for the supplement group. However, the supplement increased rates of TMV detoxification (> 50%) in only 1 of the 5 years of testing. Native cattle yielded higher rates of TMV detoxification (> 25%) in 2 of the 5 years than introduced cattle. The innate capacity to transfer rumen microbial activity between cattle in close proximity and the natural enrichment of rumen microbial populations could elevate rates of detoxification regardless of supplement or origin.
dc.language.isoen
dc.publisherSociety for Range Management
dc.relation.urlhttps://rangelands.org/
dc.rightsCopyright © Society for Range Management.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectsymptoms
dc.subjectmetabolic detoxification
dc.subjectglycosides
dc.subjectlactation number
dc.subjectprotein concentrates
dc.subjectdisease incidence
dc.subjectdisease severity
dc.subjectacute course
dc.subjectchronic diseases
dc.subjectrumen bacteria
dc.subjectanimal age
dc.subjectAstragalus miser
dc.subjectmiserotoxin
dc.subjectrumen fluids
dc.subjectpoisoning
dc.subjectBritish Columbia
dc.subjectphytotoxins
dc.subjectheifers
dc.subjectbeef cows
dc.subjectfeed supplements
dc.subjectprotein supplements
dc.subjectgrazing
dc.subjectpoisonous plants
dc.subjectpoisonous plants
dc.subjectAstragalus miser var. serotinus
dc.subjectdetoxification
dc.subjectprotein supplements
dc.titleToxicity and development of tolerance in cattle to timber milkvetch
dc.typetext
dc.typeArticle
dc.identifier.journalJournal of Range Management
dc.description.collectioninformationThe Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact lbry-journals@email.arizona.edu for further information.
dc.eprint.versionFinal published version
dc.description.admin-noteMigrated from OJS platform August 2020
dc.source.volume56
dc.source.issue3
dc.source.beginpage266-272
refterms.dateFOA2020-09-18T04:00:51Z


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