Toxicological investigations on Toano, Wasatch, and stinking milkvetches
AuthorWilliams, M. C.
MetadataShow full item record
CitationWilliams, M. C. (1989). Toxicological investigations on Toano, Wasatch, and stinking milkvetches. Journal of Range Management, 42(5), 366-368.
PublisherSociety for Range Management
JournalJournal of Range Management
AbstractToano milkvetch (Astragalus toanus Jones) synthesizes the beta-D-glucoside of 3-nitro-1-propanol (miserotoxin), a highly toxic aliphatic nitro compound, and also accumulates toxic levels of selenium. The toxicity of Toano milkvetch to 1-week-old chicks was compared with Wasatch milkvetch [Astragalus miser var. oblongifolius (Rydb.) Cronq.], which contains only miserotoxin but does not accumulate selenium; stinking milkvetch (Astragalus praelongus Sheld.), which accumulates selenium but does not contain miserotoxin; and a combination of Wasatch milkvetch and stinking milkvetch. The LD50 for chicks fed Toano milkvetch was 67.8 mg NO2/kg plus 2.7 mg Se/kg of body weight. The LD50 for Wasatch milkvetch was 105 mg NO2/kg and for stinking milkvetch 5.9 mg Se/kg. The LD50s of a combination of Wasatch milkvetch and stinking milkvetch were 66.1 mg NO2/kg and 2.7 mg Se/kg. When miserotoxin and selenium were fed together, either in Toano milkvetch or the Wasatch-stinking milkvetch combination, the LD50 for each compound was significantly lower than when they were fed separately. If seleniferous and nitro-bearing species grow sympatrically, livestock might be poisoned at lower concentrations of the individual toxic compounds if they grazed both species.