Engineering and modeling of multicellular morphologies and patterns
AffiliationUniv Arizona, Dept Mol & Cellular Biol
MetadataShow full item record
PublisherCURRENT BIOLOGY LTD
CitationKim, H., Jin, X., Glass, D. S., & Riedel-Kruse, I. H. (2020). Engineering and modeling of multicellular morphologies and patterns. Current opinion in genetics & development, 63, 95-102.
RightsCopyright © 2020 Elsevier Ltd. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractSynthetic multicellular (MC) systems have the capacity to increase our understanding of biofilms and higher organisms, and to serve as engineering platforms for developing complex products in the areas of medicine, biosynthesis and smart materials. Here we provide an interdisciplinary perspective and review on emerging approaches to engineer and model MC systems. We lay out definitions for key terms in the field and identify toolboxes of standardized parts which can be combined into various MC algorithms to achieve specific outcomes. Many essential parts and algorithms have been demonstrated in some form. As key next milestones for the field, we foresee the improvement of these parts and their adaptation to more biological systems, the demonstration of more complex algorithms, the advancement of quantitative modeling approaches and compilers to support rational MC engineering, and implementation of MC engineering for practical applications.
Note12 month embargo; available online 3 July 2020
VersionFinal accepted manuscript
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